# Can I Take Another Dose? Evaluating LLM Decision-Making Under Temporal Uncertainty in OTC Dosing QA

arXiv: https://arxiv.org/abs/2606.04262 · HTML: https://mlsanity.com/paper/2606.04262/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 10 of its 20 references that are in the map.
- First posted on arXiv 2 Jun 2026.

## Builds on (most cited first, 10 of 10)

- [The Llama 3 Herd of Models](https://mlsanity.com/paper/2407.21783/) (2024)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [SelfCheckGPT: Zero-Resource Black-Box Hallucination Detection for Generative Large Language Models](https://mlsanity.com/paper/2303.08896/) (2023)
- [Teaching Models to Express Their Uncertainty in Words](https://mlsanity.com/paper/2205.14334/) (2022)
- [A Survey of Confidence Estimation and Calibration in Large Language Models](https://mlsanity.com/paper/2311.08298/) (2023)
- [MedExQA: Medical Question Answering Benchmark with Multiple Explanations](https://mlsanity.com/paper/2406.06331/) (2024)
- [MedExpQA: Multilingual Benchmarking of Large Language Models for Medical Question Answering](https://mlsanity.com/paper/2404.05590/) (2024)
- [Uncertainty-Aware Reliable Text Classification](https://mlsanity.com/paper/2107.07114/) (2021)
- [MeDiaQA: A Question Answering Dataset on Medical Dialogues](https://mlsanity.com/paper/2108.08074/) (2021)
- [RealMedQA: A pilot biomedical question answering dataset containing realistic clinical questions](https://mlsanity.com/paper/2408.08624/) (2024)

## Abstract (arXiv)

Large language models (LLMs) are increasingly used for everyday health questions, including whether a user can safely take another dose of an over-the-counter (OTC) medication. Yet this common safety-relevant setting remains underexplored in existing medical QA evaluations, where correct answers require tracking dose timing, computing rolling 24-hour intake, following product-label constraints, and handling incomplete medication histories. We introduce DOSEBENCH, a focused benchmark of 81 curated OTC dosing scenarios focused on adult acetaminophen and ibuprofen use, with manually annotated gold references. We evaluate four LLMs across repeated runs using metrics for decision correctness, consistency, explanation verifiability, failure types, and confidence-related signals, resulting in 1,620 model responses. Our results show that models frequently struggle with rolling-window reasoning and ambiguity-sensitive cases and that stable or confident-looking responses can still violate dosing constraints. These findings suggest that OTC dosing QA provides a narrow yet practical testbed for evaluating temporal reasoning, constraint following, and safety-relevant uncertainty handling in medical QA.