# ClinicalMC: A Benchmark for Multi-Course Clinical Decision-Making with Large Language Models

arXiv: https://arxiv.org/abs/2606.03157 · HTML: https://mlsanity.com/paper/2606.03157/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 20 of its 40 references that are in the map.
- First posted on arXiv 2 Jun 2026.

## Builds on (most cited first, 20 of 20)

- [The Llama 3 Herd of Models](https://mlsanity.com/paper/2407.21783/) (2024)
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- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [The Falcon Series of Open Language Models](https://mlsanity.com/paper/2311.16867/) (2023)
- [MedAgents: Large Language Models as Collaborators for Zero-shot Medical Reasoning](https://mlsanity.com/paper/2311.10537/) (2023)
- [Agent Hospital: A Simulacrum of Hospital with Evolvable Medical Agents](https://mlsanity.com/paper/2405.02957/) (2024)
- [MMedAgent: Learning to Use Medical Tools with Multi-modal Agent](https://mlsanity.com/paper/2407.02483/) (2024)
- [AI Hospital: Benchmarking Large Language Models in a Multi-agent Medical Interaction Simulator](https://mlsanity.com/paper/2402.09742/) (2024)
- [HuatuoGPT-II, One-stage Training for Medical Adaption of LLMs](https://mlsanity.com/paper/2311.09774/) (2023)
- [Baichuan-M2: Scaling Medical Capability with Large Verifier System](https://mlsanity.com/paper/2509.02208/) (2025)
- [Publicly Shareable Clinical Large Language Model Built on Synthetic Clinical Notes](https://mlsanity.com/paper/2309.00237/) (2023)
- [CoD, Towards an Interpretable Medical Agent using Chain of Diagnosis](https://mlsanity.com/paper/2407.13301/) (2024)
- [Summarizing Patients Problems from Hospital Progress Notes Using Pre-trained Sequence-to-Sequence Models](https://mlsanity.com/paper/2208.08408/) (2022)
- [Quantifying the Reasoning Abilities of LLMs on Real-world Clinical Cases](https://mlsanity.com/paper/2503.04691/) (2025)
- [ClinicalLab: Aligning Agents for Multi-Departmental Clinical Diagnostics in the Real World](https://mlsanity.com/paper/2406.13890/) (2024)
- [Efficiently Democratizing Medical LLMs for 50 Languages via a Mixture of Language Family Experts](https://mlsanity.com/paper/2410.10626/) (2024)
- [RAMIE: Retrieval-Augmented Multi-task Information Extraction with Large Language Models on Dietary Supplements](https://mlsanity.com/paper/2411.15700/) (2024)
- [MAP: Evaluation and Multi-Agent Enhancement of Large Language Models for Inpatient Pathways](https://mlsanity.com/paper/2503.13205/) (2025)

## Abstract (arXiv)

Large language models (LLMs) have been widely adopted in healthcare, yet they still encounter significant challenges in complex clinical decision-making scenarios. Existing benchmarks primarily assess LLM performance in single-course settings and lack systematic evaluation in multi-course scenarios, where a patient's condition evolves over time. To address this gap, we propose ClinicalMC, a benchmark for multi-course clinical decision-making. It includes 1,275 Chinese and 5,804 English samples across four stages from admission to discharge. These stages cover triage, first-course examination/diagnosis/treatment, subsequent multi-course examination/assessment/treatment, and final diagnosis. In ClinicalMC, patients in the English dataset undergo an average of 5.11 clinical courses, whereas those in the Chinese dataset undergo 3.42. To assess LLM performance, we construct a multi-agent evaluation framework that includes patient, examiner, and doctor agents. Based on the benchmark and framework, we design two experimental settings -- a single-turn static setting and a multi-turn dynamic setting -- and assess three categories of LLMs: 1) closed-source LLMs like GPT5-mini; 2) open-source LLMs like DeepSeek-V3.2; and 3) medical LLMs like HuatuoGPT-o1. Through extensive evaluation, we aim to better understand LLM performance in the medical domain and support its effective deployment in healthcare.