# CAREAgent: Clinical Agent with Structured Reasoning and Tool-Integrated for Order Generation

arXiv: https://arxiv.org/abs/2606.01094 · HTML: https://mlsanity.com/paper/2606.01094/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 22 of its 29 references that are in the map.
- First posted on arXiv 31 May 2026.

## Builds on (most cited first, 22 of 22)

- [DeepSeekMath: Pushing the Limits of Mathematical Reasoning in Open Language Models](https://mlsanity.com/paper/2402.03300/) (2024)
- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Toolformer: Language Models Can Teach Themselves to Use Tools](https://mlsanity.com/paper/2302.04761/) (2023)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [MedAgents: Large Language Models as Collaborators for Zero-shot Medical Reasoning](https://mlsanity.com/paper/2311.10537/) (2023)
- [AgentClinic: a multimodal agent benchmark to evaluate AI in simulated clinical environments](https://mlsanity.com/paper/2405.07960/) (2024)
- [How Abilities in Large Language Models are Affected by Supervised Fine-tuning Data Composition](https://mlsanity.com/paper/2310.05492/) (2023)
- [A Survey of LLM-based Agents in Medicine: How far are we from Baymax?](https://mlsanity.com/paper/2502.11211/) (2025)
- [MedRAG: Enhancing Retrieval-augmented Generation with Knowledge Graph-Elicited Reasoning for Healthcare Copilot](https://mlsanity.com/paper/2502.04413/) (2025)
- [CoD, Towards an Interpretable Medical Agent using Chain of Diagnosis](https://mlsanity.com/paper/2407.13301/) (2024)
- [Quantifying the Reasoning Abilities of LLMs on Real-world Clinical Cases](https://mlsanity.com/paper/2503.04691/) (2025)
- [ClinicalLab: Aligning Agents for Multi-Departmental Clinical Diagnostics in the Real World](https://mlsanity.com/paper/2406.13890/) (2024)
- [MedResearcher-R1: Expert-Level Medical Deep Researcher via A Knowledge-Informed Trajectory Synthesis Framework](https://mlsanity.com/paper/2508.14880/) (2025)
- [ReflecTool: Towards Reflection-Aware Tool-Augmented Clinical Agents](https://mlsanity.com/paper/2410.17657/) (2024)
- [Guiding Clinical Reasoning with Large Language Models via Knowledge Seeds](https://mlsanity.com/paper/2403.06609/) (2024)
- [Medchain: Bridging the Gap Between LLM Agents and Clinical Practice with Interactive Sequence](https://mlsanity.com/paper/2412.01605/) (2024)
- [Automated radiotherapy treatment planning guided by GPT-4Vision](https://mlsanity.com/paper/2406.15609/) (2024)
- [MeNTi: Bridging Medical Calculator and LLM Agent with Nested Tool Calling](https://mlsanity.com/paper/2410.13610/) (2024)
- [End-to-End Agentic RAG System Training for Traceable Diagnostic Reasoning](https://mlsanity.com/paper/2508.15746/) (2025)
- [Integrating Physician Diagnostic Logic into Large Language Models: Preference Learning from Process Feedback](https://mlsanity.com/paper/2401.05695/) (2024)
- [MedPlan: A Two-Stage RAG-Based System for Personalized Medical Plan Generation](https://mlsanity.com/paper/2503.17900/) (2025)
- [Uncertainty-Aware Optimal Treatment Selection for Clinical Time Series](https://mlsanity.com/paper/2410.08816/) (2024)

## Abstract (arXiv)

Clinical order generation serves as a critical bridge between clinical decision-making and real-world practice, translating medical decisions into concrete and executable orders. Existing agents mainly focus on coarse-grained decisions and overlook the fine-grained, executable information required for clinical orders. To address this gap, we propose CAREAgent, an agent for clinical order generation. To support its training, we introduce a two-stage agentic reasoning data construction method. First, we design an agent framework that constructs verifiable reasoning trajectories aligned with realistic clinical tool usage. Second, we filter reasoning trajectories by format compliance, order validity, and clinical plausibility. Building on the constructed data, the model is first trained via supervised fine-tuning to acquire fundamental reasoning formats and medical knowledge, and is subsequently optimized through reinforcement learning with multi-dimensional reward functions to enhance complex clinical reasoning capabilities. Experiments on multiple benchmarks demonstrate the effectiveness of CAREAgent. On ClinicalBench (unseen during training), CAREAgent improves the F1 score by 5.05%, 2.09%, and 0.86% over the single-agent, multi-agent, and agentic reasoning methods, respectively.