# Ryze: Evidence-Enriched Data Synthesis from Biomedical Papers

arXiv: https://arxiv.org/abs/2606.00902 · HTML: https://mlsanity.com/paper/2606.00902/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical synthetic data and agents, one of 13 directions in Synthetic data and self-improvement for LLMs.
- Builds on 10 of its 18 references that are in the map.
- First posted on arXiv 30 May 2026.

## Placed in

- Synthetic data and self-improvement for LLMs / [Medical synthetic data and agents](https://mlsanity.com/synth/medical-synthetic-data-and-agents/)

## Builds on (most cited first, 10 of 10)

- [DeepSeekMath: Pushing the Limits of Mathematical Reasoning in Open Language Models](https://mlsanity.com/paper/2402.03300/) (2024)
- [Self-Instruct: Aligning Language Models with Self-Generated Instructions](https://mlsanity.com/paper/2212.10560/) (2022)
- [LlamaFactory: Unified Efficient Fine-Tuning of 100+ Language Models](https://mlsanity.com/paper/2403.13372/) (2024)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day](https://mlsanity.com/paper/2306.00890/) (2023)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [LayoutLMv2: Multi-modal Pre-training for Visually-Rich Document Understanding](https://mlsanity.com/paper/2012.14740/) (2020)
- [Nougat: Neural Optical Understanding for Academic Documents](https://mlsanity.com/paper/2308.13418/) (2023)
- [DeepSeek-OCR: Contexts Optical Compression](https://mlsanity.com/paper/2510.18234/) (2025)
- [LAB-Bench: Measuring Capabilities of Language Models for Biology Research](https://mlsanity.com/paper/2407.10362/) (2024)

## Abstract (arXiv)

General-purpose VLMs remain unreliable for biomedical research because valid answers in scientific papers depend on evidence split across figures, tables, charts, captions, and referring text. Existing post-training pipelines are bottlenecked by costly expert annotation and by synthetic data that drops this evidence structure. We present Ryze, a fully automated system that converts raw biomedical papers into an evidence-enriched training set and a domain-specialized VLM. Ryze synthesizes QA pairs with complete supporting evidence (visual element, caption, extracted structure, and referring paragraphs), reduces layout and OCR errors via chart/table-aware extraction and LLM-based cleansing, and applies a progress-gated post-training strategy combining supervised fine-tuning with reinforcement learning. Starting from Qwen3-VL-8B, Ryze produces BioVLM-8B at under USD 200, achieving 48.0% weighted accuracy on LAB-Bench, outperforming the base model by +12.6 percentage points (pp) and surpassing GPT-5.2 by +3.8 pp. We release Ryze as open source together with the trained BioVLM-8B model.