# Learning to Construct Practical Agentic Systems

arXiv: https://arxiv.org/abs/2606.00189 · HTML: https://mlsanity.com/paper/2606.00189/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in General LLM agent frameworks and benchmarks, one of 16 directions in LLM agents and tool use.
- Builds on 23 of its 35 references that are in the map.
- First posted on arXiv 29 May 2026.

## Placed in

- LLM agents and tool use / [General LLM agent frameworks and benchmarks](https://mlsanity.com/agents/general-llm-agent-frameworks-and-benchmarks/)

## Builds on (most cited first, 23 of 23)

- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Gemini 2.5: Pushing the Frontier with Advanced Reasoning, Multimodality, Long Context, and Next Generation Agentic Capabilities](https://mlsanity.com/paper/2507.06261/) (2025)
- [Challenging BIG-Bench Tasks and Whether Chain-of-Thought Can Solve Them](https://mlsanity.com/paper/2210.09261/) (2022)
- [τ-bench: A Benchmark for Tool-Agent-User Interaction in Real-World Domains](https://mlsanity.com/paper/2406.12045/) (2024)
- [Program of Thoughts Prompting: Disentangling Computation from Reasoning for Numerical Reasoning Tasks](https://mlsanity.com/paper/2211.12588/) (2022)
- [ExpeL: LLM Agents Are Experiential Learners](https://mlsanity.com/paper/2308.10144/) (2023)
- [DSPy: Compiling Declarative Language Model Calls into Self-Improving Pipelines](https://mlsanity.com/paper/2310.03714/) (2023)
- [FinQA: A Dataset of Numerical Reasoning over Financial Data](https://mlsanity.com/paper/2109.00122/) (2021)
- [GEPA: Reflective Prompt Evolution Can Outperform Reinforcement Learning](https://mlsanity.com/paper/2507.19457/) (2025)
- [AFlow: Automating Agentic Workflow Generation](https://mlsanity.com/paper/2410.10762/) (2024)
- [Automated Design of Agentic Systems](https://mlsanity.com/paper/2408.08435/) (2024)
- [Agent Workflow Memory](https://mlsanity.com/paper/2409.07429/) (2024)
- [Darwin Godel Machine: Open-Ended Evolution of Self-Improving Agents](https://mlsanity.com/paper/2505.22954/) (2025)
- [Dynamic Prompt Learning via Policy Gradient for Semi-structured Mathematical Reasoning](https://mlsanity.com/paper/2209.14610/) (2022)
- [TextGrad: Automatic "Differentiation" via Text](https://mlsanity.com/paper/2406.07496/) (2024)
- [MuSR: Testing the Limits of Chain-of-thought with Multistep Soft Reasoning](https://mlsanity.com/paper/2310.16049/) (2023)
- [A Comprehensive Survey of Self-Evolving AI Agents: A New Paradigm Bridging Foundation Models and Lifelong Agentic Systems](https://mlsanity.com/paper/2508.07407/) (2025)
- [NATURAL PLAN: Benchmarking LLMs on Natural Language Planning](https://mlsanity.com/paper/2406.04520/) (2024)
- [Inducing Programmatic Skills for Agentic Tasks](https://mlsanity.com/paper/2504.06821/) (2025)
- [MedCalc-Bench: Evaluating Large Language Models for Medical Calculations](https://mlsanity.com/paper/2406.12036/) (2024)
- [MedAgentBench: A Realistic Virtual EHR Environment to Benchmark Medical LLM Agents](https://mlsanity.com/paper/2501.14654/) (2025)
- [DesignBench: A Comprehensive Benchmark for MLLM-based Front-end Code Generation](https://mlsanity.com/paper/2506.06251/) (2025)
- [RuleArena: A Benchmark for Rule-Guided Reasoning with LLMs in Real-World Scenarios](https://mlsanity.com/paper/2412.08972/) (2024)

## Abstract (arXiv)

Automated design and optimization of agentic LLM-based systems leads to sophisticated systems that substantially improve result quality over off-the-shelf agentic patterns. However, studies of fielded agentic systems show that production systems focus much more on issues such as simplicity, controllability, and predictability of inference costs. In this paper we propose principled approaches to designing and optimizing practical agentic systems. We describe an agent framework that enables designers to enforce modularity in agentic systems, by defining "pseudo-tools" that call LLMs recursively on a restricted context. Using this framework we hand-engineer agents for a diverse set of tasks, and show that relative to dynamically-planned workflows, hand-constructed fixed workflows are generally cheaper and more accurate. We then propose novel learning methods for the agentic components required by this framework, namely pseudo-tools and fixed workflows. These learning methods generally outperform hand-engineered agents. We also exploit the modularity of the framework to apply multi-objective optimization methods to jointly optimize cost and response quality and blend the results of multiple learning systems.