# Agents that Matter: Optimizing Multi-Agent LLMs via Removal-Based Attribution

arXiv: https://arxiv.org/abs/2605.27621 · HTML: https://mlsanity.com/paper/2605.27621/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in General LLM agent frameworks and benchmarks, one of 16 directions in LLM agents and tool use.
- Builds on 36 of its 43 references that are in the map.
- First posted on arXiv 26 May 2026.

## Placed in

- LLM agents and tool use / [General LLM agent frameworks and benchmarks](https://mlsanity.com/agents/general-llm-agent-frameworks-and-benchmarks/)

## Builds on (most cited first, 30 of 36)

- [A Unified Approach to Interpreting Model Predictions](https://mlsanity.com/paper/1705.07874/) (2017)
- [Self-Consistency Improves Chain of Thought Reasoning in Language Models](https://mlsanity.com/paper/2203.11171/) (2022)
- [Gemini 2.5: Pushing the Frontier with Advanced Reasoning, Multimodality, Long Context, and Next Generation Agentic Capabilities](https://mlsanity.com/paper/2507.06261/) (2025)
- [Self-Refine: Iterative Refinement with Self-Feedback](https://mlsanity.com/paper/2303.17651/) (2023)
- [G-Eval: NLG Evaluation using GPT-4 with Better Human Alignment](https://mlsanity.com/paper/2303.16634/) (2023)
- [LiveCodeBench: Holistic and Contamination Free Evaluation of Large Language Models for Code](https://mlsanity.com/paper/2403.07974/) (2024)
- [AutoGen: Enabling Next-Gen LLM Applications via Multi-Agent Conversation](https://mlsanity.com/paper/2308.08155/) (2023)
- [MetaGPT: Meta Programming for A Multi-Agent Collaborative Framework](https://mlsanity.com/paper/2308.00352/) (2023)
- [gpt-oss-120b & gpt-oss-20b Model Card](https://mlsanity.com/paper/2508.10925/) (2025)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [AgentBench: Evaluating LLMs as Agents](https://mlsanity.com/paper/2308.03688/) (2023)
- [DeepSeek-V4: Towards Highly Efficient Million-Token Context Intelligence](https://mlsanity.com/paper/2606.19348/) (2026)
- [OpenAI GPT-5 System Card](https://mlsanity.com/paper/2601.03267/) (2025)
- [ChatDev: Communicative Agents for Software Development](https://mlsanity.com/paper/2307.07924/) (2023)
- [RISE: Randomized Input Sampling for Explanation of Black-box Models](https://mlsanity.com/paper/1806.07421/) (2018)
- [DSPy: Compiling Declarative Language Model Calls into Self-Improving Pipelines](https://mlsanity.com/paper/2310.03714/) (2023)
- [Why Do Multi-Agent LLM Systems Fail?](https://mlsanity.com/paper/2503.13657/) (2025)
- [GEPA: Reflective Prompt Evolution Can Outperform Reinforcement Learning](https://mlsanity.com/paper/2507.19457/) (2025)
- [MedAgents: Large Language Models as Collaborators for Zero-shot Medical Reasoning](https://mlsanity.com/paper/2311.10537/) (2023)
- [Explaining by Removing: A Unified Framework for Model Explanation](https://mlsanity.com/paper/2011.14878/) (2020)
- [BrowseComp-Plus: A More Fair and Transparent Evaluation Benchmark of Deep-Research Agent](https://mlsanity.com/paper/2508.06600/) (2025)
- [Which Agent Causes Task Failures and When? On Automated Failure Attribution of LLM Multi-Agent Systems](https://mlsanity.com/paper/2505.00212/) (2025)
- [MultiAgentBench: Evaluating the Collaboration and Competition of LLM agents](https://mlsanity.com/paper/2503.01935/) (2025)
- [MDAgents: An Adaptive Collaboration of LLMs for Medical Decision-Making](https://mlsanity.com/paper/2404.15155/) (2024)
- [Towards a Science of Scaling Agent Systems](https://mlsanity.com/paper/2512.08296/) (2025)
- [Should we be going MAD? A Look at Multi-Agent Debate Strategies for LLMs](https://mlsanity.com/paper/2311.17371/) (2023)
- [WorkBench: a Benchmark Dataset for Agents in a Realistic Workplace Setting](https://mlsanity.com/paper/2405.00823/) (2024)
- [MDTeamGPT: A Self-Evolving LLM-based Multi-Agent Framework for Multi-Disciplinary Team Medical Consultation](https://mlsanity.com/paper/2503.13856/) (2025)
- [DoVer: Intervention-Driven Auto Debugging for LLM Multi-Agent Systems](https://mlsanity.com/paper/2512.06749/) (2025)
- [S2-MAD: Breaking the Token Barrier to Enhance Multi-Agent Debate Efficiency](https://mlsanity.com/paper/2502.04790/) (2025)

## Abstract (arXiv)

As multi-agent systems (MAS) become increasingly complex, identifying the contributions of agents is critical for system optimization. However, existing approaches lack a unified formulation for credit assignment. In this work, we formalize agent attribution as a cooperative game, parameterized by the coalition distribution, intervention protocol, and target metric. Using this framework, we demonstrate that intervention protocols induce distinct games: Agent ablation isolates structural bottlenecks, whereas introspective LLM judges fail to faithfully approximate this behavior. We further find that Leave-One-Out (LOO) identifies bottleneck agents as effectively as combinatorial methods at much lower computational cost. Treating prompt optimization as an intervention protocol, we show that prompt-conditioned attribution can identify optimization targets and improve MAS performance. Finally, we apply our framework to audit a medical MAS, revealing that agent contributions to diagnostic accuracy and ethical behavior are often decoupled. By intervening on counterproductive roles, we observe an increase in ethics alignment while maintaining diagnostic accuracy. Overall, this work provides a principled approach for cost-effective MAS attribution and intervention.