# D3S2: Diffusion-Guided Dataset Distillation for Semantic Segmentation

arXiv: https://arxiv.org/abs/2605.25022 · HTML: https://mlsanity.com/paper/2605.25022/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 48 of its 60 references that are in the map.
- First posted on arXiv 24 May 2026.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 30 of 48)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Classifier-Free Diffusion Guidance](https://mlsanity.com/paper/2207.12598/) (2022)
- [Adding Conditional Control to Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.05543/) (2023)
- [SegFormer: Simple and Efficient Design for Semantic Segmentation with Transformers](https://mlsanity.com/paper/2105.15203/) (2021)
- [Masked-attention Mask Transformer for Universal Image Segmentation](https://mlsanity.com/paper/2112.01527/) (2021)
- [iCaRL: Incremental Classifier and Representation Learning](https://mlsanity.com/paper/1611.07725/) (2016)
- [T2I-Adapter: Learning Adapters to Dig out More Controllable Ability for Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.08453/) (2023)
- [COCO-Stuff: Thing and Stuff Classes in Context](https://mlsanity.com/paper/1612.03716/) (2016)
- [End-to-End Incremental Learning](https://mlsanity.com/paper/1807.09536/) (2018)
- [Dataset Condensation with Gradient Matching](https://mlsanity.com/paper/2006.05929/) (2020)
- [Dataset Distillation by Matching Training Trajectories](https://mlsanity.com/paper/2203.11932/) (2022)
- [Universal Guidance for Diffusion Models](https://mlsanity.com/paper/2302.07121/) (2023)
- [Dataset Condensation with Distribution Matching](https://mlsanity.com/paper/2110.04181/) (2021)
- [FreeDoM: Training-Free Energy-Guided Conditional Diffusion Model](https://mlsanity.com/paper/2303.09833/) (2023)
- [Dataset Condensation with Differentiable Siamese Augmentation](https://mlsanity.com/paper/2102.08259/) (2021)
- [Dataset Meta-Learning from Kernel Ridge-Regression](https://mlsanity.com/paper/2011.00050/) (2020)
- [Dataset Condensation via Efficient Synthetic-Data Parameterization](https://mlsanity.com/paper/2205.14959/) (2022)
- [Scaling Up Dataset Distillation to ImageNet-1K with Constant Memory](https://mlsanity.com/paper/2211.10586/) (2022)
- [Dataset Distillation using Neural Feature Regression](https://mlsanity.com/paper/2206.00719/) (2022)
- [Squeeze, Recover and Relabel: Dataset Condensation at ImageNet Scale From A New Perspective](https://mlsanity.com/paper/2306.13092/) (2023)
- [Dataset Distillation: A Comprehensive Review](https://mlsanity.com/paper/2301.07014/) (2023)
- [Generalizing Dataset Distillation via Deep Generative Prior](https://mlsanity.com/paper/2305.01649/) (2023)
- [Improved Distribution Matching for Dataset Condensation](https://mlsanity.com/paper/2307.09742/) (2023)
- [Coverage-centric Coreset Selection for High Pruning Rates](https://mlsanity.com/paper/2210.15809/) (2022)
- [Efficient Dataset Distillation Using Random Feature Approximation](https://mlsanity.com/paper/2210.12067/) (2022)
- [On the Diversity and Realism of Distilled Dataset: An Efficient Dataset Distillation Paradigm](https://mlsanity.com/paper/2312.03526/) (2023)
- [Efficient Dataset Distillation via Minimax Diffusion](https://mlsanity.com/paper/2311.15529/) (2023)

## Abstract (arXiv)

Dataset distillation (DD) aims to compress large-scale datasets into compact synthetic sets while preserving training efficacy. However, existing studies mainly focus on image classification, leaving dense prediction tasks such as semantic segmentation largely underexplored. In this work, we identify three key challenges for segmentation DD: (i) long-tailed class imbalance, (ii) the need for strict pixel-wise alignment between images and dense labels, and (iii) the high computational cost of optimizing high-resolution data with complex models. To address these challenges, we propose D3S2, a Diffusion-guided Dataset Distillation framework for Semantic Segmentation. Our method adopts a two-stage design. In Class-Balanced Mask Selection, we construct a representative mask set via a greedy strategy that prioritizes underrepresented classes. In Diffusion-Guided Image Synthesis, we employ a pretrained layout-to-image diffusion model to generate images conditioned on the selected masks, naturally ensuring spatial alignment. To further enhance the training utility of synthesized data, we introduce guided diffusion sampling with two complementary objectives: a segmentation-consistency loss for pixel-level alignment, and a class-wise feature matching loss for aligning per-class feature statistics across layers. Extensive experiments demonstrate the superiority of D3S2. Notably, at an extremely compression rate of 1%, our method achieves 24.99% and 35.49% mIoU on ADE20K and COCO-Stuff with Mask2Former (Swin-S), outperforming random selection by 9.34% and 5.70%, respectively. Our code is available at https://github.com/zwj084/D3S2.