# GlobalDentBench: A Multinational Benchmark for Evaluating LLM Clinical Reasoning in Dentistry with Expert Calibration

arXiv: https://arxiv.org/abs/2605.24636 · HTML: https://mlsanity.com/paper/2605.24636/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning.
- Builds on 13 of its 55 references that are in the map.
- First posted on arXiv 23 May 2026.

## Placed in

- LLM reasoning / [Clinical and biomedical applications](https://mlsanity.com/lr/clinical-and-biomedical-applications/)

## Builds on (most cited first, 13 of 13)

- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [DeepSeek-OCR 2: Visual Causal Flow](https://mlsanity.com/paper/2601.20552/) (2026)
- [Systematic Evaluation of LLM-as-a-Judge in LLM Alignment Tasks: Explainable Metrics and Diverse Prompt Templates](https://mlsanity.com/paper/2408.13006/) (2024)
- [A Framework for Human Evaluation of Large Language Models in Healthcare Derived from Literature Review](https://mlsanity.com/paper/2405.02559/) (2024)
- [Towards Evaluating and Building Versatile Large Language Models for Medicine](https://mlsanity.com/paper/2408.12547/) (2024)
- [Limitations of Large Language Models in Clinical Problem-Solving Arising from Inflexible Reasoning](https://mlsanity.com/paper/2502.04381/) (2025)
- [A Novel Evaluation Benchmark for Medical LLMs: Illuminating Safety and Effectiveness in Clinical Domains](https://mlsanity.com/paper/2507.23486/) (2025)
- [Automating Expert-Level Medical Reasoning Evaluation of Large Language Models](https://mlsanity.com/paper/2507.07988/) (2025)
- [Large language models provide unsafe answers to patient-posed medical questions](https://mlsanity.com/paper/2507.18905/) (2025)
- [DentVLM: A Multimodal Vision-Language Model for Comprehensive Dental Diagnosis and Enhanced Clinical Practice](https://mlsanity.com/paper/2509.23344/) (2025)
- [A Scalable Framework for Evaluating Health Language Models](https://mlsanity.com/paper/2503.23339/) (2025)
- [OralGPT-Omni: A Versatile Dental Multimodal Large Language Model](https://mlsanity.com/paper/2511.22055/) (2025)
- [DentalGPT: Incentivizing Multimodal Complex Reasoning in Dentistry](https://mlsanity.com/paper/2512.11558/) (2025)

## Abstract (arXiv)

While large language models (LLMs) hold transformative potential for medicine, their reasoning robustness and safety in real-world clinical scenarios remain critically underexplored, particularly in dentistry. Here we introduce GlobalDentBench, the first multinational dental benchmark, featuring a taxonomy that encompasses 14 dental specialties across 88 countries and regions spanning six continents. The benchmark comprises 8,978 expert-validated questions across three formats (multiple-choice, short-answer, and case-based questions) and assesses three progressive reasoning levels: knowledge recall (L1), routine reasoning (L2), and individualized reasoning (L3). To ensure data quality, the automated construction framework was calibrated by six senior dentists, achieving expert agreement rates of 99.98% for multiple-choice and short-answer questions and 96.78% for the more complex case-based questions. Evaluation of 12 frontier LLMs on GlobalDentBench revealed a sharp, stepwise performance degradation with increasing reasoning complexity. Specifically, accuracy plummeted from 81.34% on multiple-choice to 64.53% on short-answer and 22.34% on case-based questions, while declining markedly from 74.01% at L1 to 55.64% at L2 and 35.71% at L3. More critically, risk analysis of real-world dental cases demonstrated an alarming overall unsafe rate of 31.01% in LLM-generated clinical recommendations, with 4.51% posing risks of irreversible patient harm and risks particularly pronounced in specialties such as orthodontics. These findings expose fundamental limitations in the medical reasoning and safety of current LLMs. Consequently, GlobalDentBench provides a scalable foundation for trustworthy clinical AI evaluation, underscoring the urgent need for rigorous validation before the safe deployment of these models in healthcare.