# PrivFusion: A Privacy-preserving Multi-Agent Framework for Harmonizing Distributed Datasets

arXiv: https://arxiv.org/abs/2605.24249 · HTML: https://mlsanity.com/paper/2605.24249/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 8 of its 27 references that are in the map.
- First posted on arXiv 22 May 2026.

## Builds on (most cited first, 8 of 8)

- [The Llama 3 Herd of Models](https://mlsanity.com/paper/2407.21783/) (2024)
- [gpt-oss-120b & gpt-oss-20b Model Card](https://mlsanity.com/paper/2508.10925/) (2025)
- [DeepSeek-Coder: When the Large Language Model Meets Programming -- The Rise of Code Intelligence](https://mlsanity.com/paper/2401.14196/) (2024)
- [Towards Personalized Federated Learning](https://mlsanity.com/paper/2103.00710/) (2021)
- [Personalized Federated Learning: A Meta-Learning Approach](https://mlsanity.com/paper/2002.07948/) (2020)
- [Synthetic Data -- Anonymisation Groundhog Day](https://mlsanity.com/paper/2011.07018/) (2020)
- ["What do you want from theory alone?" Experimenting with Tight Auditing of Differentially Private Synthetic Data Generation](https://mlsanity.com/paper/2405.10994/) (2024)
- [The Inadequacy of Similarity-based Privacy Metrics: Privacy Attacks against "Truly Anonymous" Synthetic Datasets](https://mlsanity.com/paper/2312.05114/) (2023)

## Abstract (arXiv)

The growing availability of clinical data has increased the use of machine learning, yet centralized data aggregation is often infeasible for sensitive health information. Federated Learning (FL) offers a distributed alternative, but its adoption is limited by substantial heterogeneity across institutional datasets, making harmonization a critical but frequently overlooked prerequisite for multi-site analytics. We introduce PrivFusion, a privacy-preserving multi-agent framework that automates the harmonization of structured datasets prior to federated training. PrivFusion uses agents to analyze local data, cluster semantically similar features across sites, and provide iterative transformation recommendations until alignment is achieved. Evaluation across four heterogeneous COVID-19 datasets demonstrates that PrivFusion effectively and efficiently harmonizes multi-site data while substantially reducing manual effort.