# SegGuidedNet: Sub-Region-Aware Attention Supervision for Interpretable Brain Tumor Segmentation

arXiv: https://arxiv.org/abs/2605.22572 · HTML: https://mlsanity.com/paper/2605.22572/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 19 of its 29 references that are in the map.
- First posted on arXiv 21 May 2026.

## Builds on (most cited first, 19 of 19)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [SGDR: Stochastic Gradient Descent with Warm Restarts](https://mlsanity.com/paper/1608.03983/) (2016)
- [Delving Deep into Rectifiers: Surpassing Human-Level Performance on ImageNet Classification](https://mlsanity.com/paper/1502.01852/) (2015)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [Instance Normalization: The Missing Ingredient for Fast Stylization](https://mlsanity.com/paper/1607.08022/) (2016)
- [Swin UNETR: Swin Transformers for Semantic Segmentation of Brain Tumors in MRI Images](https://mlsanity.com/paper/2201.01266/) (2022)
- [The RSNA-ASNR-MICCAI BraTS 2021 Benchmark on Brain Tumor Segmentation and Radiogenomic Classification](https://mlsanity.com/paper/2107.02314/) (2021)
- [Identifying the Best Machine Learning Algorithms for Brain Tumor Segmentation, Progression Assessment, and Overall Survival Prediction in the BRATS Challenge](https://mlsanity.com/paper/1811.02629/) (2018)
- [3D MRI brain tumor segmentation using autoencoder regularization](https://mlsanity.com/paper/1810.11654/) (2018)
- [nnU-Net for Brain Tumor Segmentation](https://mlsanity.com/paper/2011.00848/) (2020)
- [The Brain Tumor Segmentation (BraTS) Challenge 2023: Glioma Segmentation in Sub-Saharan Africa Patient Population (BraTS-Africa)](https://mlsanity.com/paper/2305.19369/) (2023)
- [The Brain Tumor Segmentation (BraTS) Challenge 2023: Focus on Pediatrics (CBTN-CONNECT-DIPGR-ASNR-MICCAI BraTS-PEDs)](https://mlsanity.com/paper/2305.17033/) (2023)
- [Optimized U-Net for Brain Tumor Segmentation](https://mlsanity.com/paper/2110.03352/) (2021)
- [The Brain Tumor Segmentation (BraTS-METS) Challenge 2023: Brain Metastasis Segmentation on Pre-treatment MRI](https://mlsanity.com/paper/2306.00838/) (2023)
- [DeepSeg: Deep Neural Network Framework for Automatic Brain Tumor Segmentation using Magnetic Resonance FLAIR Images](https://mlsanity.com/paper/2004.12333/) (2020)
- [Redundancy Reduction in Semantic Segmentation of 3D Brain Tumor MRIs](https://mlsanity.com/paper/2111.00742/) (2021)
- [Generalized Wasserstein Dice Loss, Test-time Augmentation, and Transformers for the BraTS 2021 challenge](https://mlsanity.com/paper/2112.13054/) (2021)
- [HNF-Netv2 for Brain Tumor Segmentation using multi-modal MR Imaging](https://mlsanity.com/paper/2202.05268/) (2022)
- [Ensemble CNN Networks for GBM Tumors Segmentation using Multi-parametric MRI](https://mlsanity.com/paper/2112.06554/) (2021)

## Abstract (arXiv)

Accurate segmentation of brain tumour sub-regions from multi-parametric MRI is critical for treatment planning yet remains challenging due to morphological variability, class imbalance, and overlapping appearances of tumour regions across imaging sequences. We propose SegGuidedNet, a three-dimensional residual encoder--decoder network introducing a novel SegAttentionGate module that explicitly supervises the decoder to produce spatially discriminative attention maps for each tumour sub-region necrotic core, peritumoral oedema, and enhancing tumour via a lightweight auxiliary loss, adding less than 0.2% parameter overhead. This sub-region supervision maintains decoder discriminability between visually ambiguous classes while providing free-of-cost spatial interpretability at inference without any post-hoc explanation method. Evaluated independently on BraTS2021 and BraTS2023 GLI across 251 held-out subjects each, SegGuidedNet achieves mean Dice of 0.905 (ET= 0.873, TC=0.906, WT=0.935) and 0.897 (ET=0.859, TC=0.902, WT=0.931) respectively, surpassing ensemble-based nnU-Net and HNF-Netv2 as a single model and approaching Swin UNETR a 10-model ensemble within 2--4 Dice points at a fraction of the inference cost. The consistency of results across two benchmark editions further confirms the generalisability of the proposed approach, offering competitive accuracy with built-in interpretability in a lightweight, clinically practical framework.