# Mix-Quant: Quantized Prefilling, Precise Decoding for Agentic LLMs

arXiv: https://arxiv.org/abs/2605.20315 · HTML: https://mlsanity.com/paper/2605.20315/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Placed in Software engineering coding agents, one of 16 directions in LLM agents and tool use.
- Builds on 35 of its 40 references that are in the map.
- First posted on arXiv 19 May 2026.

## Placed in

- LLM agents and tool use / [Software engineering coding agents](https://mlsanity.com/agents/software-engineering-coding-agents/)

## Builds on (most cited first, 30 of 35)

- [Qwen3 Technical Report](https://mlsanity.com/paper/2505.09388/) (2025)
- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Efficient Memory Management for Large Language Model Serving with PagedAttention](https://mlsanity.com/paper/2309.06180/) (2023)
- [Toolformer: Language Models Can Teach Themselves to Use Tools](https://mlsanity.com/paper/2302.04761/) (2023)
- [Let's Verify Step by Step](https://mlsanity.com/paper/2305.20050/) (2023)
- [SWE-bench: Can Language Models Resolve Real-World GitHub Issues?](https://mlsanity.com/paper/2310.06770/) (2023)
- [GPTQ: Accurate Post-Training Quantization for Generative Pre-trained Transformers](https://mlsanity.com/paper/2210.17323/) (2022)
- [WebGPT: Browser-assisted question-answering with human feedback](https://mlsanity.com/paper/2112.09332/) (2021)
- [SWE-agent: Agent-Computer Interfaces Enable Automated Software Engineering](https://mlsanity.com/paper/2405.15793/) (2024)
- [MemGPT: Towards LLMs as Operating Systems](https://mlsanity.com/paper/2310.08560/) (2023)
- [SmoothQuant: Accurate and Efficient Post-Training Quantization for Large Language Models](https://mlsanity.com/paper/2211.10438/) (2022)
- [AWQ: Activation-aware Weight Quantization for LLM Compression and Acceleration](https://mlsanity.com/paper/2306.00978/) (2023)
- [A-MEM: Agentic Memory for LLM Agents](https://mlsanity.com/paper/2502.12110/) (2025)
- [LLM.int8(): 8-bit Matrix Multiplication for Transformers at Scale](https://mlsanity.com/paper/2208.07339/) (2022)
- [LongMemEval: Benchmarking Chat Assistants on Long-Term Interactive Memory](https://mlsanity.com/paper/2410.10813/) (2024)
- [LLM-Pruner: On the Structural Pruning of Large Language Models](https://mlsanity.com/paper/2305.11627/) (2023)
- [τ2-Bench: Evaluating Conversational Agents in a Dual-Control Environment](https://mlsanity.com/paper/2506.07982/) (2025)
- [DistServe: Disaggregating Prefill and Decoding for Goodput-optimized Large Language Model Serving](https://mlsanity.com/paper/2401.09670/) (2024)
- [YaRN: Efficient Context Window Extension of Large Language Models](https://mlsanity.com/paper/2309.00071/) (2023)
- [Splitwise: Efficient generative LLM inference using phase splitting](https://mlsanity.com/paper/2311.18677/) (2023)
- [LongLLMLingua: Accelerating and Enhancing LLMs in Long Context Scenarios via Prompt Compression](https://mlsanity.com/paper/2310.06839/) (2023)
- [MInference 1.0: Accelerating Pre-filling for Long-Context LLMs via Dynamic Sparse Attention](https://mlsanity.com/paper/2407.02490/) (2024)
- [LongBench v2: Towards Deeper Understanding and Reasoning on Realistic Long-context Multitasks](https://mlsanity.com/paper/2412.15204/) (2024)
- [Atom: Low-bit Quantization for Efficient and Accurate LLM Serving](https://mlsanity.com/paper/2310.19102/) (2023)
- [A Survey on Efficient Inference for Large Language Models](https://mlsanity.com/paper/2404.14294/) (2024)
- [Large Language Model Agent: A Survey on Methodology, Applications and Challenges](https://mlsanity.com/paper/2503.21460/) (2025)
- [Beyond Benchmarks: MathArena as an Evaluation Platform for Mathematics with LLMs](https://mlsanity.com/paper/2605.00674/) (2026)
- [Quantization Meets Reasoning: Exploring LLM Low-Bit Quantization Degradation for Mathematical Reasoning](https://mlsanity.com/paper/2501.03035/) (2025)
- [Bridging the Gap Between Promise and Performance for Microscaling FP4 Quantization](https://mlsanity.com/paper/2509.23202/) (2025)
- [SwiftKV: Fast Prefill-Optimized Inference with Knowledge-Preserving Model Transformation](https://mlsanity.com/paper/2410.03960/) (2024)

## Built on by (most cited first, 4 of 4)

- [HBM Is Not All You Need: Efficient Disaggregated LLM Serving across Memory-heterogeneous Accelerators](https://mlsanity.com/paper/2606.29986/) (2026)
- [Disaggregated Quantization: Specializing LLM Prefill and Decode](https://mlsanity.com/paper/2609.26333/) (2026)
- [Persistent Context Graphs for Efficient Memory Compaction in LLM Agents](https://mlsanity.com/paper/2609.40118/) (2026)
- [DuoRate: Two-Rate Per-Expert Precision Allocation for Mixture-of-Experts Serving](https://mlsanity.com/paper/2610.13328/) (2026)

## Abstract (arXiv)

LLM agents have recently emerged as a powerful paradigm for solving complex tasks through planning, tool use, memory retrieval, and multi-step interaction. However, these agentic workflows often introduce substantial input-side overhead, making the compute-intensive prefilling stage a key bottleneck in long-context, multi-turn inference. In this work, we propose Mix-Quant, a simple and effective phase-aware quantization framework for fast agentic inference. We first investigate FP4 quantization in agentic LLM workflows and observe that quantizing the entire inference process can incur significant performance degradation. In contrast, the prefilling stage exhibits substantial quantization redundancy and can therefore be quantized with minimal accuracy loss, despite being the dominant source of computation. Based on this insight, we apply high-throughput NVFP4 quantization to the prefilling phase while preserving BF16 precision for decoding. By decoupling prefilling acceleration from decoding quality, Mix-Quant combines phase-aware algorithmic quantization with hardware-efficient NVFP4 execution to alleviate the inference bottleneck in LLM agents. Extensive experiments across long-context and agentic benchmarks demonstrate that Mix-Quant largely preserves task performance while delivering significant efficiency improvements, achieving up to a 3x speedup during prefilling.