# DCFold: Efficient Protein Structure Generation with Single Forward Pass

arXiv: https://arxiv.org/abs/2605.17899 · HTML: https://mlsanity.com/paper/2605.17899/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 15 of its 43 references that are in the map.
- First posted on arXiv 18 May 2026.

## Builds on (most cited first, 15 of 15)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Flow Matching for Generative Modeling](https://mlsanity.com/paper/2210.02747/) (2022)
- [Flow Straight and Fast: Learning to Generate and Transfer Data with Rectified Flow](https://mlsanity.com/paper/2209.03003/) (2022)
- [Elucidating the Design Space of Diffusion-Based Generative Models](https://mlsanity.com/paper/2206.00364/) (2022)
- [DPM-Solver: A Fast ODE Solver for Diffusion Probabilistic Model Sampling in Around 10 Steps](https://mlsanity.com/paper/2206.00927/) (2022)
- [Consistency Models](https://mlsanity.com/paper/2303.01469/) (2023)
- [Adversarial Diffusion Distillation](https://mlsanity.com/paper/2311.17042/) (2023)
- [UniPC: A Unified Predictor-Corrector Framework for Fast Sampling of Diffusion Models](https://mlsanity.com/paper/2302.04867/) (2023)
- [Improved Techniques for Training Consistency Models](https://mlsanity.com/paper/2310.14189/) (2023)
- [Simplifying, Stabilizing and Scaling Continuous-Time Consistency Models](https://mlsanity.com/paper/2410.11081/) (2024)
- [Diffusion probabilistic modeling of protein backbones in 3D for the motif-scaffolding problem](https://mlsanity.com/paper/2206.04119/) (2022)
- [Consistency Models Made Easy](https://mlsanity.com/paper/2406.14548/) (2024)
- [FastFold: Reducing AlphaFold Training Time from 11 Days to 67 Hours](https://mlsanity.com/paper/2203.00854/) (2022)

## Built on by (most cited first, 1 of 1)

- [Few-step Cofolding with All-Atom Flow Maps](https://mlsanity.com/paper/2606.08375/) (2026)

## Abstract (arXiv)

AlphaFold3 introduces a diffusion-based architecture that elevates protein structure prediction to all-atom resolution with improved accuracy. This state-of-the-art performance has established AlphaFold3 as a foundation model for diverse generation and design tasks. However, its iterative design substantially increases inference time, limiting practical deployment in downstream settings such as virtual screening and protein design. We propose DCFold, a single-step generative model that attains AlphaFold3-level accuracy. Our Dual Consistency training framework, which incorporates a novel Temporal Geodesic Matching (TGM) scheduler, enables DCFold to achieve a 15x acceleration in inference while maintaining predictive fidelity. We validate its effectiveness across both structure prediction and binder design benchmarks.