# SynVA: A Modular Toolkit for Vessel Generation and Aneurysm Editing

arXiv: https://arxiv.org/abs/2605.17620 · HTML: https://mlsanity.com/paper/2605.17620/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 41 of its 106 references that are in the map.
- First posted on arXiv 13 May 2026.

## Builds on (most cited first, 30 of 41)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Flow Matching for Generative Modeling](https://mlsanity.com/paper/2210.02747/) (2022)
- [Scaling Rectified Flow Transformers for High-Resolution Image Synthesis](https://mlsanity.com/paper/2403.03206/) (2024)
- [OPT: Open Pre-trained Transformer Language Models](https://mlsanity.com/paper/2205.01068/) (2022)
- [Neural Message Passing for Quantum Chemistry](https://mlsanity.com/paper/1704.01212/) (2017)
- [Modeling Relational Data with Graph Convolutional Networks](https://mlsanity.com/paper/1703.06103/) (2017)
- [Improving and generalizing flow-based generative models with minibatch optimal transport](https://mlsanity.com/paper/2302.00482/) (2023)
- [Point Transformer V3: Simpler, Faster, Stronger](https://mlsanity.com/paper/2312.10035/) (2023)
- [PolyGen: An Autoregressive Generative Model of 3D Meshes](https://mlsanity.com/paper/2002.10880/) (2020)
- [Revisiting Classifier Two-Sample Tests](https://mlsanity.com/paper/1610.06545/) (2016)
- [MeshGPT: Generating Triangle Meshes with Decoder-Only Transformers](https://mlsanity.com/paper/2311.15475/) (2023)
- [Uni3D: Exploring Unified 3D Representation at Scale](https://mlsanity.com/paper/2310.06773/) (2023)
- [Michelangelo: Conditional 3D Shape Generation based on Shape-Image-Text Aligned Latent Representation](https://mlsanity.com/paper/2306.17115/) (2023)
- [MeshAnything: Artist-Created Mesh Generation with Autoregressive Transformers](https://mlsanity.com/paper/2406.10163/) (2024)
- [MeshAnything V2: Artist-Created Mesh Generation With Adjacent Mesh Tokenization](https://mlsanity.com/paper/2408.02555/) (2024)
- [MeshXL: Neural Coordinate Field for Generative 3D Foundation Models](https://mlsanity.com/paper/2405.20853/) (2024)
- [LLaMA-Mesh: Unifying 3D Mesh Generation with Language Models](https://mlsanity.com/paper/2411.09595/) (2024)
- [Meshtron: High-Fidelity, Artist-Like 3D Mesh Generation at Scale](https://mlsanity.com/paper/2412.09548/) (2024)
- [EdgeRunner: Auto-regressive Auto-encoder for Artistic Mesh Generation](https://mlsanity.com/paper/2409.18114/) (2024)
- [Scaling Mesh Generation via Compressive Tokenization](https://mlsanity.com/paper/2411.07025/) (2024)
- [DeepMesh: Auto-Regressive Artist-mesh Creation with Reinforcement Learning](https://mlsanity.com/paper/2503.15265/) (2025)
- [ImageCAS: A Large-Scale Dataset and Benchmark for Coronary Artery Segmentation based on Computed Tomography Angiography Images](https://mlsanity.com/paper/2211.01607/) (2022)
- [The TopCoW Challenge -- Topology-Aware Circle of Willis Segmentation for CT and MR Angiography](https://mlsanity.com/paper/2312.17670/) (2023)
- [PivotMesh: Generic 3D Mesh Generation via Pivot Vertices Guidance](https://mlsanity.com/paper/2405.16890/) (2024)
- [IntrA: 3D Intracranial Aneurysm Dataset for Deep Learning](https://mlsanity.com/paper/2003.02920/) (2020)
- [FastMesh: Efficient Artistic Mesh Generation via Component Decoupling](https://mlsanity.com/paper/2508.19188/) (2025)
- [VesselVAE: Recursive Variational Autoencoders for 3D Blood Vessel Synthesis](https://mlsanity.com/paper/2307.03592/) (2023)
- [Deep Learning-Based Carotid Artery Vessel Wall Segmentation in Black-Blood MRI Using Anatomical Priors](https://mlsanity.com/paper/2112.01137/) (2021)
- [MeshRipple: Structured Autoregressive Generation of Artist-Meshes](https://mlsanity.com/paper/2512.07514/) (2025)
- [3D Vessel Graph Generation Using Denoising Diffusion](https://mlsanity.com/paper/2407.05842/) (2024)

## Abstract (arXiv)

Intracranial aneurysms (IAs), characterized by unpredictable growth and risk of rupture, are a major cause of stroke and can lead to life-threatening hemorrhages with high mortality and long-term disability. With aging populations, the incidence and overall burden of cerebrovascular diseases are expected to increase, highlighting the need for scalable approaches to analyze complex medical data and improve population-level understanding of these conditions. While digital twins and deep learning offer promising avenues for improving diagnosis, prognosis, and treatment, their effectiveness is limited by the scarcity of large-scale, high-quality medical data and corresponding labels. We present Synthetic VAsculature (SynVA), a modular toolkit for vascular mesh generation and anatomically consistent aneurysm synthesis. SynVA combines novel flow-matching-based methods for generating healthy vessel meshes with learning-based approaches for anatomy-conditioned aneurysm mesh generation - aneurysms are computed from pre-existing vascular geometries rather than being generated in isolation. In addition, we introduce the SynVA procedural model for vascular and aneurysm synthesis based solely on physiological principles and statistical priors, which enables the generation of large-scale datasets (e.g., for the training of mesh-based generative models). To this end, we release a dataset of 50,000 fully labeled mesh samples for a variety of downstream vision tasks, such as semantic segmentation. Extensive quantitative and qualitative evaluations demonstrate that SynVA generates realistic vessel geometries and anatomically plausible aneurysms. Specifically, our experiments indicate that some methods produce aneurysm shapes more aligned with expert human perception while others perform better on quantitative similarity metrics with reconstructions of real aneurysms.