# Harnessing AI for Inverse Partial Differential Equation Problems: Past, Present, and Prospects

arXiv: https://arxiv.org/abs/2605.16966 · HTML: https://mlsanity.com/paper/2605.16966/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 116 of its 247 references that are in the map.
- First posted on arXiv 16 May 2026.

## Builds on (most cited first, 30 of 116)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [Proximal Policy Optimization Algorithms](https://mlsanity.com/paper/1707.06347/) (2017)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Improved Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2102.09672/) (2021)
- [Fourier Neural Operator for Parametric Partial Differential Equations](https://mlsanity.com/paper/2010.08895/) (2020)
- [DeepSDF: Learning Continuous Signed Distance Functions for Shape Representation](https://mlsanity.com/paper/1901.05103/) (2019)
- [What Uncertainties Do We Need in Bayesian Deep Learning for Computer Vision?](https://mlsanity.com/paper/1703.04977/) (2017)
- [DeepONet: Learning nonlinear operators for identifying differential equations based on the universal approximation theorem of operators](https://mlsanity.com/paper/1910.03193/) (2019)
- [Diffusion Posterior Sampling for General Noisy Inverse Problems](https://mlsanity.com/paper/2209.14687/) (2022)
- [TensorFlow: Large-Scale Machine Learning on Heterogeneous Distributed Systems](https://mlsanity.com/paper/1603.04467/) (2016)
- [DeepXDE: A deep learning library for solving differential equations](https://mlsanity.com/paper/1907.04502/) (2019)
- [The Deep Ritz method: A deep learning-based numerical algorithm for solving variational problems](https://mlsanity.com/paper/1710.00211/) (2017)
- [Solving Inverse Problems in Medical Imaging with Score-Based Generative Models](https://mlsanity.com/paper/2111.08005/) (2021)
- [Improving Diffusion Models for Inverse Problems using Manifold Constraints](https://mlsanity.com/paper/2206.00941/) (2022)
- [Fourier Neural Operator with Learned Deformations for PDEs on General Geometries](https://mlsanity.com/paper/2207.05209/) (2022)
- [PDEBENCH: An Extensive Benchmark for Scientific Machine Learning](https://mlsanity.com/paper/2210.07182/) (2022)
- [Invertible Residual Networks](https://mlsanity.com/paper/1811.00995/) (2018)
- [Denoising Diffusion Models for Plug-and-Play Image Restoration](https://mlsanity.com/paper/2305.08995/) (2023)
- [Transolver: A Fast Transformer Solver for PDEs on General Geometries](https://mlsanity.com/paper/2402.02366/) (2024)
- [Physics-informed neural networks with hard constraints for inverse design](https://mlsanity.com/paper/2102.04626/) (2021)
- [Analyzing Inverse Problems with Invertible Neural Networks](https://mlsanity.com/paper/1808.04730/) (2018)
- [Neural Operators for Accelerating Scientific Simulations and Design](https://mlsanity.com/paper/2309.15325/) (2023)
- [Solving Inverse Problems with Latent Diffusion Models via Hard Data Consistency](https://mlsanity.com/paper/2307.08123/) (2023)
- [A Survey on Diffusion Models for Inverse Problems](https://mlsanity.com/paper/2410.00083/) (2024)
- [Manifold Preserving Guided Diffusion](https://mlsanity.com/paper/2311.16424/) (2023)
- [DPOT: Auto-Regressive Denoising Operator Transformer for Large-Scale PDE Pre-Training](https://mlsanity.com/paper/2403.03542/) (2024)
- [The Well: a Large-Scale Collection of Diverse Physics Simulations for Machine Learning](https://mlsanity.com/paper/2412.00568/) (2024)
- [Linear predictors for nonlinear dynamical systems: Koopman operator meets model predictive control](https://mlsanity.com/paper/1611.03537/) (2016)

## Built on by (most cited first, 1 of 1)

- [PDE-JEPA: Predictive Representation Learning of Latent Dynamics Modeling for Parametric PDEs](https://mlsanity.com/paper/2609.34715/) (2026)

## Abstract (arXiv)

Solving inverse partial differential equation (PDE) problems is a fundamental topic in scientific research due to its broad significance across a wide range of real-world applications. Inverse PDE problems arise across medical imaging, geophysics, materials science, and aerodynamics, where the goal is to infer hidden causes, design structures, or control physical states. In this paper, we provide a comprehensive review of recent advances in solving inverse PDE problems using artificial intelligence (AI). We first introduce the basic formulation, key challenges, and traditional numerical foundations of inverse PDE problems, and then organize it into three major categories: inverse problems, inverse design, and control problems. For each category, we further present a methodological paradigms, and review representative state-of-the-art approaches from recent years. We then summarize representative applications across scientific and industrial domains, including mechanical systems, aerodynamic problems, thermal systems, full-waveform inversion, system identification, and medical imaging. Finally, we discuss open challenges and future prospects, such as physics-informed architectures, limited real-world data, uncertainty quantification, and inverse foundation models. This survey aims to provide the first unified and systematic perspective on AI for inverse PDE problems, demonstrating how modern learning-based methods are reshaping inverse problems, inverse design, and control problems in PDE-governed systems.