# Anatomy-Slot: Unsupervised Anatomical Factorization for Homologous Bilateral Reasoning in Retinal Diagnosis

arXiv: https://arxiv.org/abs/2605.12929 · HTML: https://mlsanity.com/paper/2605.12929/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 13 of its 27 references that are in the map.
- First posted on arXiv 13 May 2026.

## Builds on (most cited first, 13 of 13)

- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [Bootstrap your own latent: A new approach to self-supervised Learning](https://mlsanity.com/paper/2006.07733/) (2020)
- [DINOv3](https://mlsanity.com/paper/2508.10104/) (2025)
- [Object-Centric Learning with Slot Attention](https://mlsanity.com/paper/2006.15055/) (2020)
- [MONet: Unsupervised Scene Decomposition and Representation](https://mlsanity.com/paper/1901.11390/) (2019)
- [Multi-Object Representation Learning with Iterative Variational Inference](https://mlsanity.com/paper/1903.00450/) (2019)
- [REFUGE Challenge: A Unified Framework for Evaluating Automated Methods for Glaucoma Assessment from Fundus Photographs](https://mlsanity.com/paper/1910.03667/) (2019)
- [MedMamba: Vision Mamba for Medical Image Classification](https://mlsanity.com/paper/2403.03849/) (2024)
- [Two Eyes Are Better Than One: Exploiting Binocular Correlation for Diabetic Retinopathy Severity Grading](https://mlsanity.com/paper/2108.06763/) (2021)

## Abstract (arXiv)

Retinal diagnosis is inherently bilateral: clinicians compare homologous structures across eyes (e.g., optic disc asymmetry), yet most deep models operate on monocular representations. We investigate whether explicit structural correspondence improves diagnosis, and propose Anatomy-Slot to operationalize this hypothesis. Anatomy-Slot introduces an unsupervised anatomical bottleneck by decomposing patch tokens into a set of emergent, structurally-coherent slots that correspond to anatomical regions, then aligning these slots across eyes via bidirectional cross-attention. On ODIR-5K with n=10 seeds, the method improves AUC by 4.2 points over a matched ViT-L baseline (95% CIs; Wilcoxon signed-rank test, W=0, p=0.002). Pairing disruption and stress testing under Gaussian noise provide controlled tests of correspondence dependence and robustness under corruption. We further report quantitative optic disc grounding on REFUGE and cross-attention localization analysis. Beyond the reported gains, these results indicate that object-centric anatomical correspondence offers a principled path toward interpretable diagnostic systems aligned with clinical bilateral comparison.