# MedMemoryBench: Benchmarking Agent Memory in Personalized Healthcare

arXiv: https://arxiv.org/abs/2605.11814 · HTML: https://mlsanity.com/paper/2605.11814/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 31 of its 45 references that are in the map.
- First posted on arXiv 12 May 2026.

## Builds on (most cited first, 30 of 31)

- [WebArena: A Realistic Web Environment for Building Autonomous Agents](https://mlsanity.com/paper/2307.13854/) (2023)
- [From Local to Global: A Graph RAG Approach to Query-Focused Summarization](https://mlsanity.com/paper/2404.16130/) (2024)
- [RULER: What's the Real Context Size of Your Long-Context Language Models?](https://mlsanity.com/paper/2404.06654/) (2024)
- [ALFWorld: Aligning Text and Embodied Environments for Interactive Learning](https://mlsanity.com/paper/2010.03768/) (2020)
- [A-MEM: Agentic Memory for LLM Agents](https://mlsanity.com/paper/2502.12110/) (2025)
- [Mem0: Building Production-Ready AI Agents with Scalable Long-Term Memory](https://mlsanity.com/paper/2504.19413/) (2025)
- [LongMemEval: Benchmarking Chat Assistants on Long-Term Interactive Memory](https://mlsanity.com/paper/2410.10813/) (2024)
- [Zep: A Temporal Knowledge Graph Architecture for Agent Memory](https://mlsanity.com/paper/2501.13956/) (2025)
- [Evaluating Memory in LLM Agents via Incremental Multi-Turn Interactions](https://mlsanity.com/paper/2507.05257/) (2025)
- [MemAgent: Reshaping Long-Context LLM with Multi-Conv RL-based Memory Agent](https://mlsanity.com/paper/2507.02259/) (2025)
- [MEM1: Learning to Synergize Memory and Reasoning for Efficient Long-Horizon Agents](https://mlsanity.com/paper/2506.15841/) (2025)
- [Memory-R1: Enhancing Large Language Model Agents to Manage and Utilize Memories via Reinforcement Learning](https://mlsanity.com/paper/2508.19828/) (2025)
- [From RAG to Memory: Non-Parametric Continual Learning for Large Language Models](https://mlsanity.com/paper/2502.14802/) (2025)
- [LightMem: Lightweight and Efficient Memory-Augmented Generation](https://mlsanity.com/paper/2510.18866/) (2025)
- [MIRIX: Multi-Agent Memory System for LLM-Based Agents](https://mlsanity.com/paper/2507.07957/) (2025)
- [SimpleMem: Efficient Lifelong Memory for LLM Agents](https://mlsanity.com/paper/2601.02553/) (2026)
- [MemRL: Self-Evolving Agents via Runtime Reinforcement Learning on Episodic Memory](https://mlsanity.com/paper/2601.03192/) (2026)
- [PersonaMem-v2: Towards Personalized Intelligence via Learning Implicit User Personas and Agentic Memory](https://mlsanity.com/paper/2512.06688/) (2025)
- [MemoryArena: Benchmarking Agent Memory in Interdependent Multi-Session Agentic Tasks](https://mlsanity.com/paper/2602.16313/) (2026)
- [MemOS: An Operating System for Memory-Augmented Generation (MAG) in Large Language Models](https://mlsanity.com/paper/2505.22101/) (2025)
- [Remember Me, Refine Me: A Dynamic Procedural Memory Framework for Experience-Driven Agent Evolution](https://mlsanity.com/paper/2512.10696/) (2025)
- [Mem-α: Learning Memory Construction via Reinforcement Learning](https://mlsanity.com/paper/2509.25911/) (2025)
- [HaluMem: Evaluating Hallucinations in Memory Systems of Agents](https://mlsanity.com/paper/2511.03506/) (2025)
- [AMA-Bench: Evaluating Long-Horizon Memory for Agentic Applications](https://mlsanity.com/paper/2602.22769/) (2026)
- [From Recall to Forgetting: Benchmarking Long-Term Memory for Personalized Agents](https://mlsanity.com/paper/2604.20006/) (2026)
- [REALTALK: A 21-Day Real-World Dataset for Long-Term Conversation](https://mlsanity.com/paper/2502.13270/) (2025)
- [REMem: Reasoning with Episodic Memory in Language Agent](https://mlsanity.com/paper/2602.13530/) (2026)
- [Mem-T: Densifying Rewards for Long-Horizon Memory Agents](https://mlsanity.com/paper/2601.23014/) (2026)
- [MemoBrain: Executive Memory as an Agentic Brain for Reasoning](https://mlsanity.com/paper/2601.08079/) (2026)
- [KnowMe-Bench: Benchmarking Person Understanding for Lifelong Digital Companions](https://mlsanity.com/paper/2601.04745/) (2026)

## Built on by (most cited first, 2 of 2)

- [AgensFlow: A Coordination-Policy Substrate for Multi-Agent Systems](https://mlsanity.com/paper/2605.27466/) (2026)
- [Personalized State-Transition-Aware Memory for Clinical Agents](https://mlsanity.com/paper/2609.38490/) (2026)

## Abstract (arXiv)

The large-scale deployment of personalized healthcare agents demands memory mechanisms that are exceptionally precise, safe, and capable of long-term clinical tracking. However, existing benchmarks primarily focus on daily open-domain conversations, failing to capture the high-stakes complexity of real-world medical applications. Motivated by the stringent production requirements of an industry-leading health management agent serving tens of millions of active users, we introduce MedMemoryBench. We develop a human-agent collaborative pipeline to synthesize highly realistic, long-horizon medical trajectories based on clinically grounded, synthetic patient archetypes. This process yields a massive, expertly validated dataset comprising approximately 2,000 sessions and 16,000 interaction turns. Crucially, MedMemoryBench departs from traditional static evaluations by pioneering an "evaluate-while-constructing" streaming assessment protocol, which precisely mirrors dynamic memory accumulation in production environments. Furthermore, we formalize and systematically investigate the critical phenomenon of memory saturation, where sustained information influx actively degrades retrieval and reasoning robustness. Comprehensive benchmarking reveals severe bottlenecks in mainstream architectures, particularly concerning complex medical reasoning and noise resilience. By exposing these fundamental flaws, MedMemoryBench establishes a vital foundation for developing robust, production-ready medical agents.