# ScribbleDose: Scribble-Guided Dose Prediction in Radiotherapy

arXiv: https://arxiv.org/abs/2605.11555 · HTML: https://mlsanity.com/paper/2605.11555/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 10 of its 29 references that are in the map.
- First posted on arXiv 12 May 2026.

## Builds on (most cited first, 10 of 10)

- [PANet: Few-Shot Image Semantic Segmentation with Prototype Alignment](https://mlsanity.com/paper/1908.06391/) (2019)
- [ScribbleSup: Scribble-Supervised Convolutional Networks for Semantic Segmentation](https://mlsanity.com/paper/1604.05144/) (2016)
- [MedNeXt: Transformer-driven Scaling of ConvNets for Medical Image Segmentation](https://mlsanity.com/paper/2303.09975/) (2023)
- [MedSAM2: Segment Anything in 3D Medical Images and Videos](https://mlsanity.com/paper/2504.03600/) (2025)
- [RMT: Retentive Networks Meet Vision Transformers](https://mlsanity.com/paper/2309.11523/) (2023)
- [CycleMix: A Holistic Strategy for Medical Image Segmentation from Scribble Supervision](https://mlsanity.com/paper/2203.01475/) (2022)
- [Segment Anything Model (SAM) for Radiation Oncology](https://mlsanity.com/paper/2306.11730/) (2023)
- [DoseDiff: Distance-aware Diffusion Model for Dose Prediction in Radiotherapy](https://mlsanity.com/paper/2306.16324/) (2023)
- [Scribbles for All: Benchmarking Scribble Supervised Segmentation Across Datasets](https://mlsanity.com/paper/2408.12489/) (2024)
- [Adaptive Morph-Patch Transformer for Aortic Vessel Segmentation](https://mlsanity.com/paper/2511.06897/) (2025)

## Abstract (arXiv)

Anatomical structure masks are widely adopted in radiotherapy dose prediction, as they provide explicit geometric constraints that facilitate structure-dose coupling. However, conventional manual delineation of these masks requires precise annotation of structure boundaries relevant to radiotherapy, which is time-consuming and labor-intensive. To address these limitations, we propose a scribble-guided dose prediction framework that relies solely on anatomical structures annotated with sparse scribbles. Specifically, we design a Scribble Completion Module (SCM) to generate dense anatomical masks by propagating sparse scribble labels to semantically similar voxels. During the propagation process, a supervoxel-based regularization is introduced to preserve geometric boundary consistency to ensure anatomical plausibility. Furthermore, we propose a Structure-Guided Dose Generation Module (SGDGM) to strengthen the correspondence between sparse structural cues and dose distribution. Herein, the completed dense masks derived from scribbles serve as structural guidance to condition the dose prediction network. This scribble-mask-dose consistency encourages high-dose concentration within target volumes while effectively sparing surrounding organs-at-risk. Extensive experiments on the open-source GDP-HMM dataset demonstrate that the proposed method maintains superior dose prediction performance while substantially reducing annotation cost, providing a practical paradigm for dose prediction under sparse structural annotation. The code and reannotated scribbles are made publicly available at https://github.com/iCherishxixixi/ScribbleDose.