# CPEMH: An Agentic Framework for Prompt-Driven Behavior Evaluation and Assurance in Foundation-Model Systems for Mental Health Screening

arXiv: https://arxiv.org/abs/2605.11341 · HTML: https://mlsanity.com/paper/2605.11341/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical and scientific domain agents, one of 16 directions in LLM agents and tool use.
- Builds on 6 of its 22 references that are in the map.
- First posted on arXiv 11 May 2026.

## Placed in

- LLM agents and tool use / [Medical and scientific domain agents](https://mlsanity.com/agents/medical-and-scientific-domain-agents/)

## Builds on (most cited first, 6 of 6)

- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [Calibrate Before Use: Improving Few-Shot Performance of Language Models](https://mlsanity.com/paper/2102.09690/) (2021)
- [Large Language Models Are Human-Level Prompt Engineers](https://mlsanity.com/paper/2211.01910/) (2022)
- [Evaluation: from precision, recall and F-measure to ROC, informedness, markedness and correlation](https://mlsanity.com/paper/2010.16061/) (2020)
- [Self-collaboration Code Generation via ChatGPT](https://mlsanity.com/paper/2304.07590/) (2023)
- [Teach AI How to Code: Using Large Language Models as Teachable Agents for Programming Education](https://mlsanity.com/paper/2309.14534/) (2023)

## Abstract (arXiv)

This paper presents CPEMH, an agentic framework designed to evaluate prompt-driven behavior in foundation-model systems operating on transcript-based datasets for mental-health screening. CPEMH serves as an engineering methodology for behavioral assurance in large-scale language systems, introducing an orchestrated architecture that autonomously performs the design, evaluation, and selection of prompt strategies, enabling systematic control of behavioral variability across contexts. Its modular agentic design, combining orchestrator, inference, and evaluation agents, ensures traceability, reproducibility, and robustness throughout the prompting lifecycle. A case study on automated depression screening from interview transcripts demonstrates the framework's capacity to stabilize and audit foundation-model behavior in conversational and clinically sensitive domains. Lessons learned emphasize the role of modular orchestration in behavioral assurance, the prioritization of stability over architectural complexity, and the integration of F1, bias, and robustness as core acceptance criteria.