# Voice Biomarkers for Depression and Anxiety

arXiv: https://arxiv.org/abs/2605.09908 · HTML: https://mlsanity.com/paper/2605.09908/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 13 of its 28 references that are in the map.
- First posted on arXiv 11 May 2026.

## Builds on (most cited first, 13 of 13)

- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Exploring the Limits of Transfer Learning with a Unified Text-to-Text Transformer](https://mlsanity.com/paper/1910.10683/) (2019)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [RoBERTa: A Robustly Optimized BERT Pretraining Approach](https://mlsanity.com/paper/1907.11692/) (2019)
- [Distilling the Knowledge in a Neural Network](https://mlsanity.com/paper/1503.02531/) (2015)
- [Robust Speech Recognition via Large-Scale Weak Supervision](https://mlsanity.com/paper/2212.04356/) (2022)
- [Decoupled Weight Decay Regularization](https://mlsanity.com/paper/1711.05101/) (2017)
- [Unsupervised Data Augmentation for Consistency Training](https://mlsanity.com/paper/1904.12848/) (2019)
- [ECAPA-TDNN: Emphasized Channel Attention, Propagation and Aggregation in TDNN Based Speaker Verification](https://mlsanity.com/paper/2005.07143/) (2020)
- [Mish: A Self Regularized Non-Monotonic Activation Function](https://mlsanity.com/paper/1908.08681/) (2019)
- [TitaNet: Neural Model for speaker representation with 1D Depth-wise separable convolutions and global context](https://mlsanity.com/paper/2110.04410/) (2021)
- [Consistency Regularization Can Improve Robustness to Label Noise](https://mlsanity.com/paper/2110.01242/) (2021)
- [Parallel Algorithm for Optimal Threshold Labeling of Ordinal Regression Methods](https://mlsanity.com/paper/2405.12756/) (2024)

## Abstract (arXiv)

Current approaches to detecting depression and anxiety from speech primarily rely on machine learning techniques that utilize hand-engineered paralinguistic features and related acoustic descriptors derived from time- and frequency-domain representations of speech signals. Applying deep learning methods directly to raw speech signals has the potential to produce biomarker representations with substantially greater predictive power. However, these approaches typically require large volumes of carefully annotated data to learn robust and clinically meaningful representations of the underlying biomarkers. In this paper, we describe our efforts toward developing a deep learning model trained on a large-scale proprietary dataset comprising ~65,000 utterances collected from more than 23,000 subjects representative of relevant United States demographics. We present the techniques employed and analyze their impact on model performance. Our results demonstrate that the proposed models can extract content-agnostic biomarker information, which, when combined with lexical features extracted from audio, yields improved predictive performance in production settings. Our models are evaluated on ~5000 unique subjects and achieve performance of 71% in terms of sensitivity and specificity. To foster further research in mental health assessment from speech, we release the best-performing model described in this paper on HuggingFace.