# A Cross-Layered Multi-Drone Coordination for Medical Supply Delivery during Disaster Response Management

arXiv: https://arxiv.org/abs/2605.09342 · HTML: https://mlsanity.com/paper/2605.09342/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 3 of its 26 references that are in the map.
- First posted on arXiv 10 May 2026.

## Builds on (most cited first, 3 of 3)

- [Memory-based Deep Reinforcement Learning for Obstacle Avoidance in UAV with Limited Environment Knowledge](https://mlsanity.com/paper/1811.03307/) (2018)
- [Cellular UAV-to-X Communications: Design and Optimization for Multi-UAV Networks](https://mlsanity.com/paper/1801.05000/) (2018)
- [UAV-MARL: Multi-Agent Reinforcement Learning for Time-Critical and Dynamic Medical Supply Delivery](https://mlsanity.com/paper/2603.10528/) (2026)

## Abstract (arXiv)

Autonomous drone fleets have immense potential in medical supply delivery during disaster incident response. However, coordinating multiple drones in such settings introduces compounding challenges: dynamic environmental hazards such as wind, obstacles, and intermittent network connectivity, constrained energy budgets, and the need to serve patient locations fairly under deadlines and triage-based priority while optimizing schedule utilization. In this paper, we present CEDA, a novel CTDE Deep Q-Network algorithm for cooperative multi-drone medical delivery, designed to jointly optimize triage-priority-aware routing, multi-agent coordination, and energy-efficient navigation under dynamic uncertainty. CEDA introduces a Priority-Preserving Fair Scheduling strategy, in which a structured reward function encodes both triage weights and complementary fairness mechanisms ensuring no patient class is starved of service. We evaluate CEDA in a simulated grid environment featuring dynamic hazard zones, stochastic action failures, and dynamically spawning patients across three triage priority levels, as well as in a PX4 SITL validation using two X500 quadrotors controlled via MAVSDK in offboard position mode. Simulation results demonstrate that CEDA achieves a delivery completion rate above 85%, reduces obstacle collisions by over 90% across training, and delivers an average of 6 patients per episode with a triage efficiency of 0.82. CEDA preserves clinical priority ordering, Critical patients are served first, while achieving near-zero mortality across lower-triage classes, confirming that priority-weighted routing does not condemn Stable or Urgent patients to neglect. PX4 SITL validation further demonstrates that the learned policy remains executable and triage-coherent under practical communication constraints and realistic multi-drone coordination in disaster response settings.