# When Agents Handle Secrets: A Survey of Confidential Computing for Agentic AI

arXiv: https://arxiv.org/abs/2605.03213 · HTML: https://mlsanity.com/paper/2605.03213/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Agent threats, guardrails and governance, one of 16 directions in LLM agents and tool use.
- Builds on 56 of its 111 references that are in the map.
- First posted on arXiv 4 May 2026.

## Placed in

- LLM agents and tool use / [Agent threats, guardrails and governance](https://mlsanity.com/agents/agent-threats-guardrails-and-governance/)

## Builds on (most cited first, 30 of 56)

- [Chain-of-Thought Prompting Elicits Reasoning in Large Language Models](https://mlsanity.com/paper/2201.11903/) (2022)
- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Billion-scale similarity search with GPUs](https://mlsanity.com/paper/1702.08734/) (2017)
- [Not what you've signed up for: Compromising Real-World LLM-Integrated Applications with Indirect Prompt Injection](https://mlsanity.com/paper/2302.12173/) (2023)
- [Ignore Previous Prompt: Attack Techniques For Language Models](https://mlsanity.com/paper/2211.09527/) (2022)
- [InjecAgent: Benchmarking Indirect Prompt Injections in Tool-Integrated Large Language Model Agents](https://mlsanity.com/paper/2403.02691/) (2024)
- [A Survey on RAG Meeting LLMs: Towards Retrieval-Augmented Large Language Models](https://mlsanity.com/paper/2405.06211/) (2024)
- [Multi-Agent Collaboration Mechanisms: A Survey of LLMs](https://mlsanity.com/paper/2501.06322/) (2025)
- [A Survey on Large Language Model (LLM) Security and Privacy: The Good, the Bad, and the Ugly](https://mlsanity.com/paper/2312.02003/) (2023)
- [FLTrust: Byzantine-robust Federated Learning via Trust Bootstrapping](https://mlsanity.com/paper/2012.13995/) (2020)
- [ToolSandbox: A Stateful, Conversational, Interactive Evaluation Benchmark for LLM Tool Use Capabilities](https://mlsanity.com/paper/2408.04682/) (2024)
- [Agentic Retrieval-Augmented Generation: A Survey on Agentic RAG](https://mlsanity.com/paper/2501.09136/) (2025)
- [Gazelle: A Low Latency Framework for Secure Neural Network Inference](https://mlsanity.com/paper/1801.05507/) (2018)
- [Security and Privacy Challenges of Large Language Models: A Survey](https://mlsanity.com/paper/2402.00888/) (2024)
- [CrypTen: Secure Multi-Party Computation Meets Machine Learning](https://mlsanity.com/paper/2109.00984/) (2021)
- [The Emerged Security and Privacy of LLM Agent: A Survey with Case Studies](https://mlsanity.com/paper/2407.19354/) (2024)
- [AI Agents Under Threat: A Survey of Key Security Challenges and Future Pathways](https://mlsanity.com/paper/2406.02630/) (2024)
- [Slalom: Fast, Verifiable and Private Execution of Neural Networks in Trusted Hardware](https://mlsanity.com/paper/1806.03287/) (2018)
- [A Survey on Trustworthy LLM Agents: Threats and Countermeasures](https://mlsanity.com/paper/2503.09648/) (2025)
- [CrypTFlow2: Practical 2-Party Secure Inference](https://mlsanity.com/paper/2010.06457/) (2020)
- [RTBAS: Defending LLM Agents Against Prompt Injection and Privacy Leakage](https://mlsanity.com/paper/2502.08966/) (2025)
- [Collaborative Memory: Multi-User Memory Sharing in LLM Agents with Dynamic Access Control](https://mlsanity.com/paper/2505.18279/) (2025)
- [DarkneTZ: Towards Model Privacy at the Edge using Trusted Execution Environments](https://mlsanity.com/paper/2004.05703/) (2020)
- [A Survey of LLM-Driven AI Agent Communication: Protocols, Security Risks, and Defense Countermeasures](https://mlsanity.com/paper/2506.19676/) (2025)
- [Chiron: Privacy-preserving Machine Learning as a Service](https://mlsanity.com/paper/1803.05961/) (2018)
- [Multi-Agent Coordination across Diverse Applications: A Survey](https://mlsanity.com/paper/2502.14743/) (2025)
- [LLM Agents Should Employ Security Principles](https://mlsanity.com/paper/2505.24019/) (2025)
- [EchoLeak: The First Real-World Zero-Click Prompt Injection Exploit in a Production LLM System](https://mlsanity.com/paper/2509.10540/) (2025)
- [A Survey of Agentic AI and Cybersecurity: Challenges, Opportunities and Use-case Prototypes](https://mlsanity.com/paper/2601.05293/) (2026)
- [ShadowNet: A Secure and Efficient On-device Model Inference System for Convolutional Neural Networks](https://mlsanity.com/paper/2011.05905/) (2020)

## Abstract (arXiv)

Agentic AI systems, specifically LLM-driven agents that plan, invoke tools, maintain persistent memory, and delegate tasks to peer agents via protocols such as MCP and A2A, introduce a threat surface that differs materially from standalone model inference. Agents accumulate sensitive context, hold credentials, and operate across pipelines no single party fully controls, enabling prompt injection, context exfiltration, credential theft, and inter-agent message poisoning. Current defenses operate entirely within the software stack and can be silently bypassed by a sufficiently privileged adversary such as a compromised cloud operator. Confidential computing (CC) offers a hardware-rooted alternative: Trusted Execution Environments (TEEs) isolate agent code and data from privileged system software, while remote attestation enables verifiable trust across distributed deployments. This survey synthesizes the design space in four parts: (i) a unified taxonomy of six TEE platforms (Intel SGX, Intel TDX, AMD SEV-SNP, ARM TrustZone, ARM CCA, and NVIDIA H100 CC) covering deployment roles and performance tradeoffs; (ii) an agent-centric threat model spanning perception, planning, memory, action, and coordination layers mapped to nine security goals; (iii) a comparative survey of CC-based defenses distinguishing findings that transfer from single-call inference versus what requires new agentic designs; and (iv) six open challenges including compound attestation for multi-hop agent chains and GPU-TEE performance at LLM scale. While several hardware trust primitives appear mature enough for targeted deployments, no broadly established end-to-end framework yet binds them into a coherent security substrate for production agentic AI.