# ADAPTS: Agentic Decomposition for Automated Protocol-agnostic Tracking of Symptoms

arXiv: https://arxiv.org/abs/2605.03212 · HTML: https://mlsanity.com/paper/2605.03212/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Medical and scientific domain agents, one of 16 directions in LLM agents and tool use.
- Builds on 8 of its 30 references that are in the map.
- First posted on arXiv 4 May 2026.

## Placed in

- LLM agents and tool use / [Medical and scientific domain agents](https://mlsanity.com/agents/medical-and-scientific-domain-agents/)

## Builds on (most cited first, 8 of 8)

- [Chain-of-Thought Prompting Elicits Reasoning in Large Language Models](https://mlsanity.com/paper/2201.11903/) (2022)
- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Lost in the Middle: How Language Models Use Long Contexts](https://mlsanity.com/paper/2307.03172/) (2023)
- [WhisperX: Time-Accurate Speech Transcription of Long-Form Audio](https://mlsanity.com/paper/2303.00747/) (2023)
- [pyannote.audio: neural building blocks for speaker diarization](https://mlsanity.com/paper/1911.01255/) (2019)
- [fairseq S2T: Fast Speech-to-Text Modeling with fairseq](https://mlsanity.com/paper/2010.05171/) (2020)
- [Investigation of Whisper ASR Hallucinations Induced by Non-Speech Audio](https://mlsanity.com/paper/2501.11378/) (2025)
- [DAIC-WOZ: On the Validity of Using the Therapist's prompts in Automatic Depression Detection from Clinical Interviews](https://mlsanity.com/paper/2404.14463/) (2024)

## Built on by (most cited first, 1 of 1)

- [The MADRS Pipeline: Supporting Depression Assessment in Clinical Trials](https://mlsanity.com/paper/2607.28190/) (2026)

## Abstract (arXiv)

Modeling latent clinical constructs from unconstrained clinical interactions is a unique challenge in affective computing. We present ADAPTS (Agentic Decomposition for Automated Protocol-agnostic Tracking of Symptoms), a framework for automated rating of depression and anxiety severity using a mixture-of-agents LLM architecture. This approach decomposes long-form clinical interviews into symptom-specific reasoning tasks, producing auditable justifications while preserving temporal and speaker alignment. Generalization was evaluated across two independent datasets (N=204) with distinct interview structures. On high-discrepancy interviews, automated ratings approximated expert benchmarks (absolute error=22) more closely than original human ratings (absolute error=26). Implementing an ``extended'' protocol that incorporates qualitative clinical conventions significantly stabilized ratings, with absolute agreement reaching ICC(2,1) = 0.877. These findings suggest that the ADAPTS framework enables promising evaluations of psychiatric severity. While the current implementation is purely text-based, the underlying architecture is readily extensible to multimodal inputs, including acoustic and visual features. By approximating expert-level precision in a protocol-agnostic manner, this framework provides a foundation for objective and scalable psychiatric assessment, especially in resource-limited settings.