# Federated Semi-Supervised Graph Neural Networks with Prototype-Guided Pseudo-Labeling for Privacy-Preserving Gestational Diabetes Mellitus Prediction

arXiv: https://arxiv.org/abs/2605.01810 · HTML: https://mlsanity.com/paper/2605.01810/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 15 of its 41 references that are in the map.
- First posted on arXiv 3 May 2026.

## Builds on (most cited first, 15 of 15)

- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [Semi-Supervised Classification with Graph Convolutional Networks](https://mlsanity.com/paper/1609.02907/) (2016)
- [Communication-Efficient Learning of Deep Networks from Decentralized Data](https://mlsanity.com/paper/1602.05629/) (2016)
- [Inductive Representation Learning on Large Graphs](https://mlsanity.com/paper/1706.02216/) (2017)
- [Federated Optimization in Heterogeneous Networks](https://mlsanity.com/paper/1812.06127/) (2018)
- [Fast Graph Representation Learning with PyTorch Geometric](https://mlsanity.com/paper/1903.02428/) (2019)
- [FixMatch: Simplifying Semi-Supervised Learning with Consistency and Confidence](https://mlsanity.com/paper/2001.07685/) (2020)
- [The Future of Digital Health with Federated Learning](https://mlsanity.com/paper/2003.08119/) (2020)
- [FedBN: Federated Learning on Non-IID Features via Local Batch Normalization](https://mlsanity.com/paper/2102.07623/) (2021)
- [GRAND: Graph Neural Diffusion](https://mlsanity.com/paper/2106.10934/) (2021)
- [Subgraph Federated Learning with Missing Neighbor Generation](https://mlsanity.com/paper/2106.13430/) (2021)
- [Federated Semi-Supervised Learning with Inter-Client Consistency & Disjoint Learning](https://mlsanity.com/paper/2006.12097/) (2020)
- [FedGL: Federated Graph Learning Framework with Global Self-Supervision](https://mlsanity.com/paper/2105.03170/) (2021)
- [RSCFed: Random Sampling Consensus Federated Semi-supervised Learning](https://mlsanity.com/paper/2203.13993/) (2022)
- [SpreadGNN: Serverless Multi-task Federated Learning for Graph Neural Networks](https://mlsanity.com/paper/2106.02743/) (2021)

## Abstract (arXiv)

Gestational Diabetes Mellitus (GDM) is a high-prevalence pregnancy complication that requires accurate early risk stratification to reduce maternal and fetal morbidity. However, real-world clinical deployment of machine learning is hindered by two coupled constraints: (i) label scarcity, where a large fraction of electronic health records (EHR) lack confirmed diagnostic labels, and (ii) data privacy, which prevents sharing patient-level data across hospitals. This paper proposes FedTGNN-SS, a privacy-preserving federated semi-supervised framework for clinical tabular EHR. Each hospital builds a local k-nearest-neighbor patient similarity graph and trains a topology-adaptive GNN encoder. To robustly exploit unlabeled records, FedTGNN-SS combines (1) prototype-guided pseudo-labeling with neighborhood agreement, (2) adaptive graph refinement that periodically updates the k-NN graph using learned embeddings, (3) clinical-aware consistency augmentation applied only to continuous variables, and (4) privacy-safe prototype sharing that exchanges only class-level centroids. Across three diabetes-related datasets (GDM: N = 3,525; Pima: N = 768; Early Stage: N = 520) under 10%-80% missing labels per silo, FedTGNN-SS achieves 56 significant wins (p < 0.05) against 11 federated baselines and attains strong AUROC under extreme scarcity (Pima: 0.8037 at 80% missing, Early Stage: 0.9634 at 80% missing).