# A Hybrid Retrieval and Reranking Framework for Evidence-Grounded Retrieval-Augmented Generation

arXiv: https://arxiv.org/abs/2605.01664 · HTML: https://mlsanity.com/paper/2605.01664/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical and biomedical RAG, one of 15 directions in Retrieval-augmented generation.
- Builds on 28 of its 43 references that are in the map.
- First posted on arXiv 3 May 2026.

## Placed in

- Retrieval-augmented generation / [Medical and biomedical RAG](https://mlsanity.com/rag/medical-and-biomedical-rag/)

## Builds on (most cited first, 28 of 28)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks](https://mlsanity.com/paper/2005.11401/) (2020)
- [Dense Passage Retrieval for Open-Domain Question Answering](https://mlsanity.com/paper/2004.04906/) (2020)
- [REALM: Retrieval-Augmented Language Model Pre-Training](https://mlsanity.com/paper/2002.08909/) (2020)
- [Survey of Hallucination in Natural Language Generation](https://mlsanity.com/paper/2202.03629/) (2022)
- [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://mlsanity.com/paper/1901.08746/) (2019)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [MS MARCO: A Human Generated MAchine Reading COmprehension Dataset](https://mlsanity.com/paper/1611.09268/) (2016)
- [FEVER: a large-scale dataset for Fact Extraction and VERification](https://mlsanity.com/paper/1803.05355/) (2018)
- [Improving language models by retrieving from trillions of tokens](https://mlsanity.com/paper/2112.04426/) (2021)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [FActScore: Fine-grained Atomic Evaluation of Factual Precision in Long Form Text Generation](https://mlsanity.com/paper/2305.14251/) (2023)
- [BEIR: A Heterogenous Benchmark for Zero-shot Evaluation of Information Retrieval Models](https://mlsanity.com/paper/2104.08663/) (2021)
- [Unsupervised Dense Information Retrieval with Contrastive Learning](https://mlsanity.com/paper/2112.09118/) (2021)
- [Leveraging Passage Retrieval with Generative Models for Open Domain Question Answering](https://mlsanity.com/paper/2007.01282/) (2020)
- [ColBERT: Efficient and Effective Passage Search via Contextualized Late Interaction over BERT](https://mlsanity.com/paper/2004.12832/) (2020)
- [Domain-Specific Language Model Pretraining for Biomedical Natural Language Processing](https://mlsanity.com/paper/2007.15779/) (2020)
- [Enabling Large Language Models to Generate Text with Citations](https://mlsanity.com/paper/2305.14627/) (2023)
- [Fact or Fiction: Verifying Scientific Claims](https://mlsanity.com/paper/2004.14974/) (2020)
- [ClinicalBERT: Modeling Clinical Notes and Predicting Hospital Readmission](https://mlsanity.com/paper/1904.05342/) (2019)
- [ColBERTv2: Effective and Efficient Retrieval via Lightweight Late Interaction](https://mlsanity.com/paper/2112.01488/) (2021)
- [Ragas: Automated Evaluation of Retrieval Augmented Generation](https://mlsanity.com/paper/2309.15217/) (2023)
- [SPLADE: Sparse Lexical and Expansion Model for First Stage Ranking](https://mlsanity.com/paper/2107.05720/) (2021)
- [GatorTron: A Large Clinical Language Model to Unlock Patient Information from Unstructured Electronic Health Records](https://mlsanity.com/paper/2203.03540/) (2022)
- [A Study of Generative Large Language Model for Medical Research and Healthcare](https://mlsanity.com/paper/2305.13523/) (2023)
- [From Generative Modeling to Clinical Classification: A GPT-Based Architecture for EHR Notes](https://mlsanity.com/paper/2601.21955/) (2026)
- [Selective Fine-Tuning of GPT Architectures for Parameter-Efficient Clinical Text Classification](https://mlsanity.com/paper/2603.14183/) (2026)

## Abstract (arXiv)

Retrieval-augmented generation (RAG) improves large language model reliability by grounding generated responses in external evidence. However, RAG performance depends on the relevance of retrieved passages, the quality of evidence ranking, and the ability to verify whether generated claims are supported by source documents. This study presents a hybrid retrieval and reranking framework for citation-aware RAG in biomedical and healthcare-related document question answering. The framework uses Amazon Bedrock Knowledge Bases for document ingestion, parsing, chunking, embedding generation, and evidence retrieval. Source PDF documents are stored in Amazon S3, embedded using Amazon Titan Text Embeddings V2, and indexed with Amazon OpenSearch Serverless. Hybrid retrieval first retrieves candidate evidence chunks, and Cohere reranking then prioritizes the most relevant passages before answer generation. The answer-generation stage uses top-ranked evidence chunks to produce controlled, evidence-grounded responses, while a separate judge model evaluates each generated factual claim against the retrieved evidence. The framework was evaluated using 25 biomedical NLP and healthcare transformer queries as a pilot-scale proof-of-concept study. Across the evaluation set, the system retrieved and reranked 500 evidence chunks and generated answers from top-ranked evidence. Claim-level grounding evaluation extracted 200 factual claims, all of which were judged to be supported by retrieved evidence, resulting in 100.0% grounding accuracy. The results suggest that hybrid retrieval, reranking, conservative prompting, and claim-level evaluation can support reliable evidence-grounded RAG responses when sufficient source evidence is available.