# ReMedi: Reasoner for Medical Clinical Prediction

arXiv: https://arxiv.org/abs/2605.01474 · HTML: https://mlsanity.com/paper/2605.01474/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning.
- Builds on 16 of its 55 references that are in the map.
- First posted on arXiv 2 May 2026.

## Placed in

- LLM reasoning / [Clinical and biomedical applications](https://mlsanity.com/lr/clinical-and-biomedical-applications/)

## Builds on (most cited first, 16 of 16)

- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [The Llama 3 Herd of Models](https://mlsanity.com/paper/2407.21783/) (2024)
- [DeepSeek-R1: Incentivizing Reasoning Capability in LLMs via Reinforcement Learning](https://mlsanity.com/paper/2501.12948/) (2025)
- [Decoupled Weight Decay Regularization](https://mlsanity.com/paper/1711.05101/) (2017)
- [s1: Simple test-time scaling](https://mlsanity.com/paper/2501.19393/) (2025)
- [Gemini: A Family of Highly Capable Multimodal Models](https://mlsanity.com/paper/2312.11805/) (2023)
- [RAFT: Reward rAnked FineTuning for Generative Foundation Model Alignment](https://mlsanity.com/paper/2304.06767/) (2023)
- [MedGemma Technical Report](https://mlsanity.com/paper/2507.05201/) (2025)
- [Scaling Relationship on Learning Mathematical Reasoning with Large Language Models](https://mlsanity.com/paper/2308.01825/) (2023)
- [HuatuoGPT-o1, Towards Medical Complex Reasoning with LLMs](https://mlsanity.com/paper/2412.18925/) (2024)
- [SelfCheck: Using LLMs to Zero-Shot Check Their Own Step-by-Step Reasoning](https://mlsanity.com/paper/2308.00436/) (2023)
- [MedReason: Eliciting Factual Medical Reasoning Steps in LLMs via Knowledge Graphs](https://mlsanity.com/paper/2504.00993/) (2025)
- [Bootstrap Your Own Skills: Learning to Solve New Tasks with Large Language Model Guidance](https://mlsanity.com/paper/2310.10021/) (2023)
- [Baichuan-M1: Pushing the Medical Capability of Large Language Models](https://mlsanity.com/paper/2502.12671/) (2025)
- [CodeJudgeBench: Benchmarking LLM-as-a-Judge for Coding Tasks](https://mlsanity.com/paper/2507.10535/) (2025)
- [Representation Learning of Structured Data for Medical Foundation Models](https://mlsanity.com/paper/2410.13351/) (2024)

## Built on by (most cited first, 1 of 1)

- [Can Large Language Models Anticipate Behavioral Responses to Social Policies? A Case of Pension Enrollment Prediction among China's Flexible Workers](https://mlsanity.com/paper/2609.05189/) (2026)

## Abstract (arXiv)

Predicting future clinical outcomes from electronic health records (EHR) remains challenging due to the complexity and heterogeneity of patient data. LLMs have shown strong potential for such predictive tasks, yet existing approaches mainly focus on enhancing medical knowledge through distillation or RAG while relying on the model's internal ability to interpret contextual information. In this work, we present ReMedi (Reasoner for Medical Clinical Prediction), a framework for improving clinical outcome prediction from EHR. ReMedi generates rationale-answer pairs using a challenging sample regeneration mechanism for complex clinical questions, which leverages ground-truth answers as hints to enhance reasoning for further fine-tuning and preference tuning. ReMedi integrates ground-truth outcome guidance into the preference data construction loop, regenerating rationale-answer variants. By tuning on these rationale-answer pairs, the model improves its predictive performance. Experiments on multiple EHR prediction tasks demonstrate substantial gains of up to 19.9 percent over state-of-the-art baselines in terms of F1 score, underscoring ReMedi's effectiveness in real-world clinical prediction.