# ClinicBot: A Guideline-Grounded Clinical Chatbot with Prioritized Evidence RAG and Verifiable Citations

arXiv: https://arxiv.org/abs/2605.00846 · HTML: https://mlsanity.com/paper/2605.00846/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 9 of its 21 references that are in the map.
- First posted on arXiv 11 Apr 2026.

## Builds on (most cited first, 9 of 9)

- [Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks](https://mlsanity.com/paper/2005.11401/) (2020)
- [Dense Passage Retrieval for Open-Domain Question Answering](https://mlsanity.com/paper/2004.04906/) (2020)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [A Survey on Hallucination in Large Language Models: Principles, Taxonomy, Challenges, and Open Questions](https://mlsanity.com/paper/2311.05232/) (2023)
- [Interleaving Retrieval with Chain-of-Thought Reasoning for Knowledge-Intensive Multi-Step Questions](https://mlsanity.com/paper/2212.10509/) (2022)
- [Large Language Models Can Be Easily Distracted by Irrelevant Context](https://mlsanity.com/paper/2302.00093/) (2023)
- [MedCPT: Contrastive Pre-trained Transformers with Large-scale PubMed Search Logs for Zero-shot Biomedical Information Retrieval](https://mlsanity.com/paper/2307.00589/) (2023)
- [MedRAG: Enhancing Retrieval-augmented Generation with Knowledge Graph-Elicited Reasoning for Healthcare Copilot](https://mlsanity.com/paper/2502.04413/) (2025)
- [A Comprehensive Survey on the Trustworthiness of Large Language Models in Healthcare](https://mlsanity.com/paper/2502.15871/) (2025)

## Built on by (most cited first, 2 of 2)

- [Inform, Coach, Relate, Listen: Auditing LLM Caregiving Support Roles](https://mlsanity.com/paper/2605.29473/) (2026)
- [From PDF to Evidence: Structure-Aware Retrieval for Clinical Practice Guidelines](https://mlsanity.com/paper/2609.33447/) (2026)

## Abstract (arXiv)

Clinical diagnosis requires answers that are accurate, verifiable, and explicitly grounded in official guidelines. While large language models excel at natural language processing, their tendency to hallucinate undermines their utility in high-stakes medical contexts where precision is essential. Existing retrieval-augmented generation (RAG) systems treat all evidence equally, producing noisy context and generic answers misaligned with clinical practice. We present ClinicBot, an AI system that translates guideline recommendations into trustworthy clinical support through three key advances: (1) structured extraction of clinical guidelines into semantic units (recommendations, tables, definitions, narrative) with explicit provenance, (2) evidence prioritization that ranks content by clinical significance and guideline structure rather than textual similarity, and (3) a web-based interface that presents concise, actionable answers with verifiable evidence. We will demonstrate ClinicBot using diabetes questions from real patients and an additional diabetes risk assessment tool that is faithful to the American Diabetes Association (ADA) Standards of Care in Diabetes (2025). The demonstration will illustrate how semantic knowledge extraction and hierarchical evidence ranking can reliably operate in a multi-agent setting to process complex clinical guidelines at scale.