# Multi-frame Restoration for 10 Hz Lissajous Confocal Laser Endomicroscopy

arXiv: https://arxiv.org/abs/2605.00527 · HTML: https://mlsanity.com/paper/2605.00527/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 13 of its 28 references that are in the map.
- First posted on arXiv 1 May 2026.

## Builds on (most cited first, 13 of 13)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [PWC-Net: CNNs for Optical Flow Using Pyramid, Warping, and Cost Volume](https://mlsanity.com/paper/1709.02371/) (2017)
- [Optical Flow Estimation using a Spatial Pyramid Network](https://mlsanity.com/paper/1611.00850/) (2016)
- [BasicVSR++: Improving Video Super-Resolution with Enhanced Propagation and Alignment](https://mlsanity.com/paper/2104.13371/) (2021)
- [Rethinking Coarse-to-Fine Approach in Single Image Deblurring](https://mlsanity.com/paper/2108.05054/) (2021)
- [Recurrent Video Restoration Transformer with Guided Deformable Attention](https://mlsanity.com/paper/2206.02146/) (2022)
- [Efficient Frequency Domain-based Transformers for High-Quality Image Deblurring](https://mlsanity.com/paper/2211.12250/) (2022)
- [Intriguing Findings of Frequency Selection for Image Deblurring](https://mlsanity.com/paper/2111.11745/) (2021)
- [Efficient Multi-Stage Video Denoising with Recurrent Spatio-Temporal Fusion](https://mlsanity.com/paper/2103.05407/) (2021)
- [Real-time Streaming Video Denoising with Bidirectional Buffers](https://mlsanity.com/paper/2207.06937/) (2022)
- [Learning Truncated Causal History Model for Video Restoration](https://mlsanity.com/paper/2410.03936/) (2024)
- [MedVSR: Medical Video Super-Resolution with Cross State-Space Propagation](https://mlsanity.com/paper/2509.21265/) (2025)
- [Motion Artifact Detection in Confocal Laser Endomicroscopy Images](https://mlsanity.com/paper/1711.01117/) (2017)

## Abstract (arXiv)

Lissajous confocal laser endomicroscopy (CLE) is a promising solution for high-speed in vivo optical biopsy for handheld scenarios. However, Lissajous scanning traces a resonant trajectory and samples only the visited pixels per frame; at high frame rates, many pixels remain unvisited, creating structured holes. In this work, we introduce the first benchmark for 10 Hz Lissajous CLE, consisting of low-quality video clips paired with high-quality reference images. The reference images are wide-FOV mosaics obtained by stitching stabilized, slow-scan frames of the same tissue, enabling temporally aligned supervision. Using this dataset, we propose MIRA, a lightweight recurrent framework for Lissajous CLE restoration that iteratively aggregates temporal context through feature reuse and displacement alignment. Our experiments demonstrate that MIRA outperforms both lightweight and high-complexity baselines in restoration quality while maintaining a favorable computational efficiency suitable for clinical deployment.