# Asynchronous Federated Unlearning with Invariance Calibration for Medical Imaging

arXiv: https://arxiv.org/abs/2604.26809 · HTML: https://mlsanity.com/paper/2604.26809/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Federated unlearning and poisoning, one of 12 directions in LLM safety and security.
- Builds on 19 of its 29 references that are in the map.
- First posted on arXiv 29 Apr 2026.

## Placed in

- LLM safety and security / [Federated unlearning and poisoning](https://mlsanity.com/safety/federated-unlearning-and-poisoning/)

## Builds on (most cited first, 19 of 19)

- [Communication-Efficient Learning of Deep Networks from Decentralized Data](https://mlsanity.com/paper/1602.05629/) (2016)
- [Overcoming catastrophic forgetting in neural networks](https://mlsanity.com/paper/1612.00796/) (2016)
- [Invariant Risk Minimization](https://mlsanity.com/paper/1907.02893/) (2019)
- [Federated Learning: Challenges, Methods, and Future Directions](https://mlsanity.com/paper/1908.07873/) (2019)
- [Measuring the Effects of Non-Identical Data Distribution for Federated Visual Classification](https://mlsanity.com/paper/1909.06335/) (2019)
- [MedMNIST v2 -- A large-scale lightweight benchmark for 2D and 3D biomedical image classification](https://mlsanity.com/paper/2110.14795/) (2021)
- [A Survey of Machine Unlearning](https://mlsanity.com/paper/2209.02299/) (2022)
- [Asynchronous Federated Optimization](https://mlsanity.com/paper/1903.03934/) (2019)
- [Federated Unlearning via Class-Discriminative Pruning](https://mlsanity.com/paper/2110.11794/) (2021)
- [Federated Unlearning: How to Efficiently Erase a Client in FL?](https://mlsanity.com/paper/2207.05521/) (2022)
- [Federated Unlearning with Knowledge Distillation](https://mlsanity.com/paper/2201.09441/) (2022)
- [A Survey on Federated Unlearning: Challenges, Methods, and Future Directions](https://mlsanity.com/paper/2310.20448/) (2023)
- [Frequency-Aligned Knowledge Distillation for Lightweight Spatiotemporal Forecasting](https://mlsanity.com/paper/2507.02939/) (2025)
- [Federated Unlearning: A Survey on Methods, Design Guidelines, and Evaluation Metrics](https://mlsanity.com/paper/2401.05146/) (2024)
- [Federated Unlearning with Gradient Descent and Conflict Mitigation](https://mlsanity.com/paper/2412.20200/) (2024)
- [Unlearning during Learning: An Efficient Federated Machine Unlearning Method](https://mlsanity.com/paper/2405.15474/) (2024)
- [MMT-ARD: Multimodal Multi-Teacher Adversarial Distillation for Robust Vision-Language Models](https://mlsanity.com/paper/2511.17448/) (2025)
- [SRKD: Towards Efficient 3D Point Cloud Segmentation via Structure- and Relation-aware Knowledge Distillation](https://mlsanity.com/paper/2506.17290/) (2025)
- [FedQUIT: On-Device Federated Unlearning via a Quasi-Competent Virtual Teacher](https://mlsanity.com/paper/2408.07587/) (2024)

## Abstract (arXiv)

Federated Unlearning (FU) is an emerging paradigm in Federated Learning (FL) that enables participating clients to fully remove their contributions from a trained global model, driven by data protection regulations that mandate the right to be forgotten. However, existing FU methods mostly rely on synchronous coordination. This requirement forces the entire federation to halt and wait for stragglers to complete erasure, creating significant delays due to device heterogeneity. Furthermore, these methods often face the problem that the influence of erased data is merely suppressed temporarily and resurfaces during subsequent training, rather than being genuinely removed. To overcome these limitations, this paper proposes Asynchronous Federated Unlearning with Invariance Calibration (AFU-IC), a novel framework for medical imaging that decouples the erasure process from the global training workflow. This enables the target client to perform unlearning asynchronously without interrupting global training. Meanwhile, a server-side invariance calibration mechanism prevents the model from relearning the erased data. Extensive experiments on three medical benchmarks demonstrate that AFU-IC achieves unlearning efficacy and model fidelity comparable to gold-standard retraining while significantly reducing wall-clock latency compared to synchronous baselines. AFU-IC ensures efficient, compliant and reliable FL in cross-silo medical environments.