# NeuroPlastic: A Plasticity-Modulated Optimizer for Biologically Inspired Learning Dynamics

arXiv: https://arxiv.org/abs/2604.26297 · HTML: https://mlsanity.com/paper/2604.26297/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 18 of its 37 references that are in the map.
- First posted on arXiv 29 Apr 2026.

## Builds on (most cited first, 18 of 18)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [Fashion-MNIST: a Novel Image Dataset for Benchmarking Machine Learning Algorithms](https://mlsanity.com/paper/1708.07747/) (2017)
- [Optimizing Neural Networks with Kronecker-factored Approximate Curvature](https://mlsanity.com/paper/1503.05671/) (2015)
- [Learning to learn by gradient descent by gradient descent](https://mlsanity.com/paper/1606.04474/) (2016)
- [Symbolic Discovery of Optimization Algorithms](https://mlsanity.com/paper/2302.06675/) (2023)
- [Shampoo: Preconditioned Stochastic Tensor Optimization](https://mlsanity.com/paper/1802.09568/) (2018)
- [Direct Feedback Alignment Provides Learning in Deep Neural Networks](https://mlsanity.com/paper/1609.01596/) (2016)
- [Difference Target Propagation](https://mlsanity.com/paper/1412.7525/) (2014)
- [Differentiable plasticity: training plastic neural networks with backpropagation](https://mlsanity.com/paper/1804.02464/) (2018)
- [Learning with Differentiable Perturbed Optimizers](https://mlsanity.com/paper/2002.08676/) (2020)
- [Towards an integration of deep learning and neuroscience](https://mlsanity.com/paper/1606.03813/) (2016)
- [Eligibility Traces and Plasticity on Behavioral Time Scales: Experimental Support of neoHebbian Three-Factor Learning Rules](https://mlsanity.com/paper/1801.05219/) (2018)
- [A Theoretical Framework for Target Propagation](https://mlsanity.com/paper/2006.14331/) (2020)
- [Kronecker-Factored Approximate Curvature for Modern Neural Network Architectures](https://mlsanity.com/paper/2311.00636/) (2023)
- [Backpropamine: training self-modifying neural networks with differentiable neuromodulated plasticity](https://mlsanity.com/paper/2002.10585/) (2020)
- [Efficient Non-Parametric Optimizer Search for Diverse Tasks](https://mlsanity.com/paper/2209.13575/) (2022)

## Abstract (arXiv)

Optimization algorithms are fundamental to modern deep learning, yet most widely used methods rely on update rules based primarily on local gradient statistics. We introduce NeuroPlastic, a plasticity-modulated optimizer that augments gradient-based updates with an adaptive multi-signal modulation mechanism inspired by multi-factor synaptic plasticity, a concept from neurobiology. NeuroPlastic dynamically scales gradient updates using interacting components that capture gradient, activity-like, and memory-like statistics, forming a lightweight modulation layer compatible with standard deep learning training pipelines. Across image classification benchmarks, NeuroPlastic consistently improves over a controlled gradient-only ablation, with more pronounced gains on the Fashion-MNIST benchmark and in reduced-data regimes. In transfer experiments on CIFAR-10 with ResNet-18, the method remains stable and competitive without retuning. These results suggest that multi-signal plasticity-inspired modulation can provide a useful extension to conventional gradient-driven optimization, particularly when learning signals are limited or noisy, and offer a promising direction for gradient-based methods in deep learning.