# SCOPE:Planning for Hybrid Querying over Clinical Trial Data

arXiv: https://arxiv.org/abs/2604.25120 · HTML: https://mlsanity.com/paper/2604.25120/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 12 of its 36 references that are in the map.
- First posted on arXiv 28 Apr 2026.

## Builds on (most cited first, 12 of 12)

- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Spider: A Large-Scale Human-Labeled Dataset for Complex and Cross-Domain Semantic Parsing and Text-to-SQL Task](https://mlsanity.com/paper/1809.08887/) (2018)
- [Seq2SQL: Generating Structured Queries from Natural Language using Reinforcement Learning](https://mlsanity.com/paper/1709.00103/) (2017)
- [Compositional Semantic Parsing on Semi-Structured Tables](https://mlsanity.com/paper/1508.00305/) (2015)
- [TAPAS: Weakly Supervised Table Parsing via Pre-training](https://mlsanity.com/paper/2004.02349/) (2020)
- [TabFact: A Large-scale Dataset for Table-based Fact Verification](https://mlsanity.com/paper/1909.02164/) (2019)
- [TaBERT: Pretraining for Joint Understanding of Textual and Tabular Data](https://mlsanity.com/paper/2005.08314/) (2020)
- [Binding Language Models in Symbolic Languages](https://mlsanity.com/paper/2210.02875/) (2022)
- [BlendSQL: A Scalable Dialect for Unifying Hybrid Question Answering in Relational Algebra](https://mlsanity.com/paper/2402.17882/) (2024)
- [Better Call CLAUSE: A Discrepancy Benchmark for Auditing LLMs Legal Reasoning Capabilities](https://mlsanity.com/paper/2511.00340/) (2025)
- [FD-NL2SQL: Feedback-Driven Clinical NL2SQL that Improves with Use](https://mlsanity.com/paper/2604.15646/) (2026)

## Built on by (most cited first, 1 of 1)

- [Answering clinicians' questions over trial evidence tables with verifiable, feedback-driven language models](https://mlsanity.com/paper/2610.02576/) (2026)

## Abstract (arXiv)

We study clinical trial table reasoning, where answers are not directly stored in visible cells but must be reasoned from semantic understanding through normalization, classification, extraction, or lightweight domain reasoning. Motivated by the observation that current LLM approaches often suffer from "bad reasoning" under implicit planning assumptions, we focus on settings in which the model must recover implicit attributes such as therapy type, added agents, endpoint roles, or follow-up status from partially observed clinical-trial tables. We propose SCOPE (Structured Clinical hybrid Planning for Evidence retrieval in clinical trials), a multi-LLM planner-based framework that decomposes the task into row selection, structured planning, and execution. The planner makes the source field, reasoning rules, and output constraints explicit before answer generation, reducing ambiguity relative to direct prompting. We evaluate SCOPE on 1,500 hybrid reasoning questions over oncology clinical-trial tables against zero-shot, few-shot, chain-of-thought, TableGPT2, Blend-SQL, and EHRAgent. Results show that explicit multi-LLM planning improves accuracy for reasoning-based questions while offering a stronger accuracy-efficiency tradeoff than heavier agentic baselines. Our findings position clinical trial reasoning as a distinct table understanding problem and highlight hybrid planner-based decomposition as an effective solution