# SemiGDA: Generative Dual-distribution Alignment for Semi-Supervised Medical Image Segmentation

arXiv: https://arxiv.org/abs/2604.23274 · HTML: https://mlsanity.com/paper/2604.23274/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 28 of its 53 references that are in the map.
- First posted on arXiv 25 Apr 2026.

## Builds on (most cited first, 28 of 28)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [A ConvNet for the 2020s](https://mlsanity.com/paper/2201.03545/) (2022)
- [Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2105.05537/) (2021)
- [Skin Lesion Analysis Toward Melanoma Detection 2018: A Challenge Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1902.03368/) (2019)
- [Kvasir-SEG: A Segmented Polyp Dataset](https://mlsanity.com/paper/1911.07069/) (2019)
- [Semi-Supervised Semantic Segmentation with Cross Pseudo Supervision](https://mlsanity.com/paper/2106.01226/) (2021)
- [PraNet: Parallel Reverse Attention Network for Polyp Segmentation](https://mlsanity.com/paper/2006.11392/) (2020)
- [Uncertainty-aware Self-ensembling Model for Semi-supervised 3D Left Atrium Segmentation](https://mlsanity.com/paper/1907.07034/) (2019)
- [A Benchmark for Endoluminal Scene Segmentation of Colonoscopy Images](https://mlsanity.com/paper/1612.00799/) (2016)
- [Semi-supervised Medical Image Segmentation through Dual-task Consistency](https://mlsanity.com/paper/2009.04448/) (2020)
- [Revisiting Weak-to-Strong Consistency in Semi-Supervised Semantic Segmentation](https://mlsanity.com/paper/2208.09910/) (2022)
- [Semi-supervised Left Atrium Segmentation with Mutual Consistency Training](https://mlsanity.com/paper/2103.02911/) (2021)
- [GMMSeg: Gaussian Mixture based Generative Semantic Segmentation Models](https://mlsanity.com/paper/2210.02025/) (2022)
- [Learning with Limited Annotations: A Survey on Deep Semi-Supervised Learning for Medical Image Segmentation](https://mlsanity.com/paper/2207.14191/) (2022)
- [Enhancing Pseudo Label Quality for Semi-Supervised Domain-Generalized Medical Image Segmentation](https://mlsanity.com/paper/2201.08657/) (2022)
- [Generative Semantic Segmentation](https://mlsanity.com/paper/2303.11316/) (2023)
- [Correlation-Aware Mutual Learning for Semi-supervised Medical Image Segmentation](https://mlsanity.com/paper/2307.06312/) (2023)
- [Learnable Prompting SAM-induced Knowledge Distillation for Semi-supervised Medical Image Segmentation](https://mlsanity.com/paper/2412.13742/) (2024)
- [Alternate Diverse Teaching for Semi-supervised Medical Image Segmentation](https://mlsanity.com/paper/2311.17325/) (2023)
- [Synthetic Augmentation with Large-scale Unconditional Pre-training](https://mlsanity.com/paper/2308.04020/) (2023)
- [Duo-SegNet: Adversarial Dual-Views for Semi-Supervised Medical Image Segmentation](https://mlsanity.com/paper/2108.11154/) (2021)
- [A Survey on Deep Learning for Polyp Segmentation: Techniques, Challenges and Future Trends](https://mlsanity.com/paper/2311.18373/) (2023)
- [Semi-supervised Pathological Image Segmentation via Cross Distillation of Multiple Attentions](https://mlsanity.com/paper/2305.18830/) (2023)
- [Generative Medical Segmentation](https://mlsanity.com/paper/2403.18198/) (2024)
- [PMT: Progressive Mean Teacher via Exploring Temporal Consistency for Semi-Supervised Medical Image Segmentation](https://mlsanity.com/paper/2409.05122/) (2024)
- [Uncertainty-aware Cross-training for Semi-supervised Medical Image Segmentation](https://mlsanity.com/paper/2508.09014/) (2025)
- [Text-driven Multiplanar Visual Interaction for Semi-supervised Medical Image Segmentation](https://mlsanity.com/paper/2507.12382/) (2025)

## Abstract (arXiv)

Semi-supervised learning addresses label scarcity and high annotation costs in medical image segmentation by exploiting the latent information in unlabeled data to enhance model performance. Traditional discriminative segmentation relies on segmentation masks, neglecting feature-level distribution constraints. This limits robust semantic representation learning and adaptive modeling of unlabeled data in scenarios with few labels. To address these limitations, we propose SemiGDA, a novel Generative Dual-distribution Alignment framework for semi-supervised medical image segmentation. Our SemiGDA overcomes the reliance of discriminative methods on large labeled datasets by aligning feature and semantic distributions to boost semantic learning and scene adaptability. Specifically, we propose a Dual-distribution Alignment Module (DAM), which employs two structurally distinct encoders to model image and mask feature distributions. It enforces their alignment in the latent space via distributional constraints, establishing structured feature consistency. Moreover, we design a Consistency-Driven Skip Adapter (CDSA) strategy, which introduces dual skip adapters (Image and Mask) to fuse multi-scale features via skip connections. Using a consistency loss, CDSA enhances cross-branch semantic alignment and reinforces fine-grained semantic consistency. Experimental results on diverse medical datasets show that our method outperforms other state-of-the-art semi-supervised segmentation methods. Code is released at: https://github.com/taozh2017/SemiGDA.