# Deep Learning for Model Calibration in Simulation of Itaconic Acid Production

arXiv: https://arxiv.org/abs/2604.22496 · HTML: https://mlsanity.com/paper/2604.22496/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 1 of its 27 references that are in the map.
- First posted on arXiv 24 Apr 2026.

## Builds on (most cited first, 1 of 1)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)

## Abstract (arXiv)

In this study, deep learning is used to estimate kinetic parameters for modeling itaconic acid production based on real batch experiments conducted at different agitation speeds and reactor scales. Two deep learning strategies, namely direct deep learning (DDL) and generative conditional flow matching (CFM) are compared and benchmarked against nonlinear regression as a reference method. Compared with DDL, CFM consistently yields more accurate results. The concentration profiles predicted by CFM closely match those obtained from nonlinear regression, whereas DDL results in larger deviations. Similar behavior is observed in the scale-up experiments, where the CFM model again generalizes better and is more robust than the direct approach. These findings demonstrate that CFM can reliably predict system behavior across different operating conditions and scales, offering a flexible and data-efficient framework for parameter estimation in dynamic bioprocess models.