# An Artifact-based Agent Framework for Adaptive and Reproducible Medical Image Processing

arXiv: https://arxiv.org/abs/2604.21936 · HTML: https://mlsanity.com/paper/2604.21936/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 8 of its 20 references that are in the map.
- First posted on arXiv 31 Mar 2026.

## Builds on (most cited first, 8 of 8)

- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Toolformer: Language Models Can Teach Themselves to Use Tools](https://mlsanity.com/paper/2302.04761/) (2023)
- [Generative Agents: Interactive Simulacra of Human Behavior](https://mlsanity.com/paper/2304.03442/) (2023)
- [TotalSegmentator: robust segmentation of 104 anatomical structures in CT images](https://mlsanity.com/paper/2208.05868/) (2022)
- [HACA3: A Unified Approach for Multi-site MR Image Harmonization](https://mlsanity.com/paper/2212.06065/) (2022)
- [Beyond the LUMIR challenge: The pathway to foundational registration models](https://mlsanity.com/paper/2505.24160/) (2025)
- [Time-distance vision transformers in lung cancer diagnosis from longitudinal computed tomography](https://mlsanity.com/paper/2209.01676/) (2022)
- [Harmonization-enriched domain adaptation with light fine-tuning for multiple sclerosis lesion segmentation](https://mlsanity.com/paper/2310.20586/) (2023)

## Built on by (most cited first, 1 of 1)

- [Volumetric Radiology AI in the Era of Multimodal Large Language Models](https://mlsanity.com/paper/2608.20549/) (2026)

## Abstract (arXiv)

Medical imaging research is increasingly shifting from controlled benchmark evaluation toward real-world clinical deployment. In such settings, applying analytical methods extends beyond model design to require dataset-aware workflow configuration and provenance tracking. Two requirements therefore become central: adaptability, the ability to configure workflows according to dataset-specific conditions and evolving analytical goals; and reproducibility, the guarantee that all transformations and decisions are explicitly recorded and re-executable. Here, we present an artifact-based agent framework that introduces a semantic layer to augment medical image processing. The framework formalizes intermediate and final outputs through an artifact contract, enabling structured interrogation of workflow state and goal-conditioned assembly of configurations from a modular rule library. Execution is delegated to a workflow executor to preserve deterministic computational graph construction and provenance tracking, while the agent operates locally to comply with most privacy constraints. We evaluate the framework on real-world clinical CT and MRI cohorts, demonstrating adaptive configuration synthesis, deterministic reproducibility across repeated executions, and artifact-grounded semantic querying. These results show that adaptive workflow configuration can be achieved without compromising reproducibility in heterogeneous clinical environments.