# Conditional Evidence Reconstruction and Decomposition for Interpretable Multimodal Diagnosis

arXiv: https://arxiv.org/abs/2604.17030 · HTML: https://mlsanity.com/paper/2604.17030/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 13 of its 25 references that are in the map.
- First posted on arXiv 18 Apr 2026.

## Builds on (most cited first, 13 of 13)

- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [A Unified Approach to Interpreting Model Predictions](https://mlsanity.com/paper/1705.07874/) (2017)
- ["Why Should I Trust You?": Explaining the Predictions of Any Classifier](https://mlsanity.com/paper/1602.04938/) (2016)
- [Axiomatic Attribution for Deep Networks](https://mlsanity.com/paper/1703.01365/) (2017)
- [Counterfactual Explanations without Opening the Black Box: Automated Decisions and the GDPR](https://mlsanity.com/paper/1711.00399/) (2017)
- [SMIL: Multimodal Learning with Severely Missing Modality](https://mlsanity.com/paper/2103.05677/) (2021)
- [Multimodal Generative Models for Scalable Weakly-Supervised Learning](https://mlsanity.com/paper/1802.05335/) (2018)
- [What Clinicians Want: Contextualizing Explainable Machine Learning for Clinical End Use](https://mlsanity.com/paper/1905.05134/) (2019)
- [HeMIS: Hetero-Modal Image Segmentation](https://mlsanity.com/paper/1607.05194/) (2016)
- [Deep Multimodal Learning with Missing Modality: A Survey](https://mlsanity.com/paper/2409.07825/) (2024)
- [Generalized Multimodal ELBO](https://mlsanity.com/paper/2105.02470/) (2021)
- [M3Care: Learning with Missing Modalities in Multimodal Healthcare Data](https://mlsanity.com/paper/2210.17292/) (2022)
- [Flex-MoE: Modeling Arbitrary Modality Combination via the Flexible Mixture-of-Experts](https://mlsanity.com/paper/2410.08245/) (2024)

## Abstract (arXiv)

Neurobiological and neurodegenerative diseases are inherently multifactorial, arising from coupled influences spanning genetic susceptibility, brain alterations, and environmental and behavioral factors. Multimodal modeling has therefore been increasingly adopted for disease diagnosis by integrating complementary evidence across data sources. However, in both large-scale cohorts and real-world clinical workflows, modality coverage is often incomplete, making many multimodal models brittle when one or more modalities are unavailable. Existing approaches to incomplete multimodal diagnosis typically rely on group-wise or static priors, which may fail to capture subject-specific cross-modal dependencies; moreover, many models provide limited interpretability into which evidence sources drive the final decision. To address these limitations, we propose Conditional Evidence Reconstruction and Decomposition (CERD), a framework for interpretable multimodal diagnosis with incomplete modalities. CERD first reconstructs missing modality representations conditioned on each subject's observed inputs, then decomposes diagnostic evidence into shared cross-modal corroboration and modality-specific cues via logit-level attribution. Experiments on the Alzheimer's Disease Neuroimaging Initiative (ADNI) demonstrate that CERD outperforms competitive baselines under incomplete-modality settings while producing structured and clinically aligned evidence attributions for trustworthy decision support.