# Hybrid Quantum-Classical PINNs for Scientific Computing: A Multi-GPU Open-Source Framework

arXiv: https://arxiv.org/abs/2604.15645 · HTML: https://mlsanity.com/paper/2604.15645/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 31 of its 75 references that are in the map.
- First posted on arXiv 17 Apr 2026.

## Builds on (most cited first, 30 of 31)

- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [Switch Transformers: Scaling to Trillion Parameter Models with Simple and Efficient Sparsity](https://mlsanity.com/paper/2101.03961/) (2021)
- [Implicit Neural Representations with Periodic Activation Functions](https://mlsanity.com/paper/2006.09661/) (2020)
- [Fourier Features Let Networks Learn High Frequency Functions in Low Dimensional Domains](https://mlsanity.com/paper/2006.10739/) (2020)
- [Megatron-LM: Training Multi-Billion Parameter Language Models Using Model Parallelism](https://mlsanity.com/paper/1909.08053/) (2019)
- [GShard: Scaling Giant Models with Conditional Computation and Automatic Sharding](https://mlsanity.com/paper/2006.16668/) (2020)
- [On the Spectral Bias of Neural Networks](https://mlsanity.com/paper/1806.08734/) (2018)
- [Mixed Precision Training](https://mlsanity.com/paper/1710.03740/) (2017)
- [GradNorm: Gradient Normalization for Adaptive Loss Balancing in Deep Multitask Networks](https://mlsanity.com/paper/1711.02257/) (2017)
- [Characterizing possible failure modes in physics-informed neural networks](https://mlsanity.com/paper/2109.01050/) (2021)
- [When and why PINNs fail to train: A neural tangent kernel perspective](https://mlsanity.com/paper/2007.14527/) (2020)
- [Efficient Large-Scale Language Model Training on GPU Clusters Using Megatron-LM](https://mlsanity.com/paper/2104.04473/) (2021)
- [DeepXDE: A deep learning library for solving differential equations](https://mlsanity.com/paper/1907.04502/) (2019)
- [Weight Normalization: A Simple Reparameterization to Accelerate Training of Deep Neural Networks](https://mlsanity.com/paper/1602.07868/) (2016)
- [Physics-informed neural networks with hard constraints for inverse design](https://mlsanity.com/paper/2102.04626/) (2021)
- [A comprehensive study of non-adaptive and residual-based adaptive sampling for physics-informed neural networks](https://mlsanity.com/paper/2207.10289/) (2022)
- [Challenges in Training PINNs: A Loss Landscape Perspective](https://mlsanity.com/paper/2402.01868/) (2024)
- [A Method for Representing Periodic Functions and Enforcing Exactly Periodic Boundary Conditions with Deep Neural Networks](https://mlsanity.com/paper/2007.07442/) (2020)
- [PINNacle: A Comprehensive Benchmark of Physics-Informed Neural Networks for Solving PDEs](https://mlsanity.com/paper/2306.08827/) (2023)
- [FINER: Flexible spectral-bias tuning in Implicit NEural Representation by Variable-periodic Activation Functions](https://mlsanity.com/paper/2312.02434/) (2023)
- [From PINNs to PIKANs: Recent Advances in Physics-Informed Machine Learning](https://mlsanity.com/paper/2410.13228/) (2024)
- [PirateNets: Physics-informed Deep Learning with Residual Adaptive Networks](https://mlsanity.com/paper/2402.00326/) (2024)
- [Evolutional Deep Neural Network](https://mlsanity.com/paper/2103.09959/) (2021)
- [A unified scalable framework for causal sweeping strategies for Physics-Informed Neural Networks (PINNs) and their temporal decompositions](https://mlsanity.com/paper/2302.14227/) (2023)
- [Physics-Guided Deep Learning for Dynamical Systems: A Survey](https://mlsanity.com/paper/2107.01272/) (2021)
- [Simulating Three-dimensional Turbulence with Physics-informed Neural Networks](https://mlsanity.com/paper/2507.08972/) (2025)
- [Random Weight Factorization Improves the Training of Continuous Neural Representations](https://mlsanity.com/paper/2210.01274/) (2022)
- [On the Generalization of PINNs outside the training domain and the Hyperparameters influencing it](https://mlsanity.com/paper/2302.07557/) (2023)
- [Nys-Newton: Nystr"om-Approximated Curvature for Stochastic Optimization](https://mlsanity.com/paper/2110.08577/) (2021)
- [Adaptive Interface-PINNs (AdaI-PINNs): An Efficient Physics-informed Neural Networks Framework for Interface Problems](https://mlsanity.com/paper/2406.04626/) (2024)

## Abstract (arXiv)

We present QPINNACLE, an open-source computational framework for physics-informed neural networks (PINNs) that integrates modern training strategies, multi-GPU acceleration, and hybrid quantum-classical architectures within a unified modular workflow. The framework enables systematic evaluation of PINN performance across benchmark problems including 1D hyperbolic conservation laws, incompressible flows, and electromagnetic wave propagation. It supports a range of architectural and training enhancements, including Fourier feature embeddings, random weight factorization, strict boundary condition enforcement, adaptive loss balancing, curriculum training, and second-order optimization strategies, with extensibility to additional methods. We provide a comprehensive benchmark study quantifying the impact of these methods on convergence, accuracy, and computational cost, and analyze distributed data parallel scaling in terms of runtime and memory efficiency. In addition, we extend the framework to hybrid quantum-classical PINNs and derive a formal estimate for circuit-evaluation complexity under parameter-shift differentiation. Results highlight the sensitivity of PINNs to architectural and training choices, confirm their high computational cost relative to classical solvers, and identify regimes where hybrid quantum models offer improved parameter efficiency. QPINNACLE provides a foundation for benchmarking physics-informed learning methods and guiding future developments through quantitative assessment of their trade-offs.