# Autogenesis: A Self-Evolving Agent Protocol

arXiv: https://arxiv.org/abs/2604.15034 · HTML: https://mlsanity.com/paper/2604.15034/

## Key facts

- Cited by 13 papers in the map (data through 14 Oct 2026).
- Placed in General LLM agent frameworks and benchmarks, one of 16 directions in LLM agents and tool use.
- Builds on 33 of its 50 references that are in the map.
- First posted on arXiv 16 Apr 2026.

## Placed in

- LLM agents and tool use / [General LLM agent frameworks and benchmarks](https://mlsanity.com/agents/general-llm-agent-frameworks-and-benchmarks/)
- Synthetic data and self-improvement for LLMs / [Self-evolving LLM agents](https://mlsanity.com/synth/self-evolving-llm-agents/)

## Builds on (most cited first, 30 of 33)

- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [Proximal Policy Optimization Algorithms](https://mlsanity.com/paper/1707.06347/) (2017)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [Chain-of-Thought Prompting Elicits Reasoning in Large Language Models](https://mlsanity.com/paper/2201.11903/) (2022)
- [DeepSeekMath: Pushing the Limits of Mathematical Reasoning in Open Language Models](https://mlsanity.com/paper/2402.03300/) (2024)
- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Evaluating Large Language Models Trained on Code](https://mlsanity.com/paper/2107.03374/) (2021)
- [Reflexion: Language Agents with Verbal Reinforcement Learning](https://mlsanity.com/paper/2303.11366/) (2023)
- [Toolformer: Language Models Can Teach Themselves to Use Tools](https://mlsanity.com/paper/2302.04761/) (2023)
- [Self-Refine: Iterative Refinement with Self-Feedback](https://mlsanity.com/paper/2303.17651/) (2023)
- [SWE-bench: Can Language Models Resolve Real-World GitHub Issues?](https://mlsanity.com/paper/2310.06770/) (2023)
- [GPQA: A Graduate-Level Google-Proof Q&A Benchmark](https://mlsanity.com/paper/2311.12022/) (2023)
- [Fine-Tuning Language Models from Human Preferences](https://mlsanity.com/paper/1909.08593/) (2019)
- [AutoGen: Enabling Next-Gen LLM Applications via Multi-Agent Conversation](https://mlsanity.com/paper/2308.08155/) (2023)
- [ToolLLM: Facilitating Large Language Models to Master 16000+ Real-world APIs](https://mlsanity.com/paper/2307.16789/) (2023)
- [MetaGPT: Meta Programming for A Multi-Agent Collaborative Framework](https://mlsanity.com/paper/2308.00352/) (2023)
- [GAIA: a benchmark for General AI Assistants](https://mlsanity.com/paper/2311.12983/) (2023)
- [Large Language Models Are Human-Level Prompt Engineers](https://mlsanity.com/paper/2211.01910/) (2022)
- [STaR: Bootstrapping Reasoning With Reasoning](https://mlsanity.com/paper/2203.14465/) (2022)
- [Automatic Prompt Optimization with "Gradient Descent" and Beam Search](https://mlsanity.com/paper/2305.03495/) (2023)
- [AgentVerse: Facilitating Multi-Agent Collaboration and Exploring Emergent Behaviors](https://mlsanity.com/paper/2308.10848/) (2023)
- [Self-Play Fine-Tuning Converts Weak Language Models to Strong Language Models](https://mlsanity.com/paper/2401.01335/) (2024)
- [A Survey of Self-Evolving Agents: What, When, How, and Where to Evolve on the Path to Artificial Super Intelligence](https://mlsanity.com/paper/2507.21046/) (2025)
- [Alita: Generalist Agent Enabling Scalable Agentic Reasoning with Minimal Predefinition and Maximal Self-Evolution](https://mlsanity.com/paper/2505.20286/) (2025)
- [ScoreFlow: Mastering LLM Agent Workflows via Score-based Preference Optimization](https://mlsanity.com/paper/2502.04306/) (2025)
- [ToolOrchestra: Elevating Intelligence via Efficient Model and Tool Orchestration](https://mlsanity.com/paper/2511.21689/) (2025)
- [EvoAgentX: An Automated Framework for Evolving Agentic Workflows](https://mlsanity.com/paper/2507.03616/) (2025)
- [From Mind to Machine: The Rise of Manus AI as a Fully Autonomous Digital Agent](https://mlsanity.com/paper/2505.02024/) (2025)
- [AWorld: Orchestrating the Training Recipe for Agentic AI](https://mlsanity.com/paper/2508.20404/) (2025)

## Built on by (most cited first, 13 of 13)

- [From Failed Trajectories to Reliable LLM Agents: Diagnosing and Repairing Harness Flaws](https://mlsanity.com/paper/2606.06324/) (2026)
- [SkillsVote: Lifecycle Governance of Agent Skills from Collection, Recommendation to Evolution](https://mlsanity.com/paper/2605.18401/) (2026)
- [Code Is the Body: Agent-Owned Software Bodies for Recursive Evolution and Descent](https://mlsanity.com/paper/2607.28691/) (2026)
- [Ouroboros: A Self-Developing Frontier Coding Agent with Reviewed Core Evolution](https://mlsanity.com/paper/2608.08311/) (2026)
- [Runtime-Independent Persistent Agents: Preserving Identity, Memory, and Code Across Models, Harnesses, and Servers](https://mlsanity.com/paper/2609.00546/) (2026)
- [MetaRSI / RSI2: A Meta-Recursive Self-Improving System for Recursive Self-Improving Systems Themselves](https://mlsanity.com/paper/2609.06396/) (2026)
- [Governed Collaborative Memory as Artificial Selection in LLM-Based Multi-Agent Systems](https://mlsanity.com/paper/2605.04264/) (2026)
- [ABot-AgentOS: A General Robotic Agent OS with Lifelong Multi-modal Memory](https://mlsanity.com/paper/2607.10350/) (2026)
- [Beyond Component Testing: Validating Agentic AI Systems](https://mlsanity.com/paper/2607.29405/) (2026)
- [Continual Learning in Transition](https://mlsanity.com/paper/2608.06216/) (2026)
- [The Empire, Long Divided, Must Unite: Architectural Convergence in Three LLM Agent Harnesses](https://mlsanity.com/paper/2608.23953/) (2026)
- [Authorization for Self-Modifying AI Agent Populations: Conserving Authority across Replacement, Forking, and Rollback](https://mlsanity.com/paper/2610.00347/) (2026)
- [HarnessNet: Feedback-driven Hierarchical Joint Harness Evolution for Multi-agent Systems](https://mlsanity.com/paper/2610.15221/) (2026)

## Abstract (arXiv)

LLM-based agent systems can adapt by revising prompts, constructing tools, and changing other runtime resources. Managing these heterogeneous updates requires a shared lifecycle for identifying targets, assessing candidates, and retaining accepted versions, complementing communication protocols such as A2A and MCP. We introduce AUTOGENESIS PROTOCOL (AGP), which decouples what evolves from how updates are proposed. Its Resource Substrate Protocol Layer (RSPL) represents prompts, agents, tools, environments, and memory as protocol-registered resources with explicit state and versioned interfaces. Its Self-Evolution Protocol Layer (SEPL) specifies candidate proposal, assessment, and commit, with auditable histories and support for restoring retained resource states. We instantiate AGP in AUTOGENESIS SYSTEM (AGS), a self-evolving multi-agent system that retrieves, instantiates, and refines resources during execution. Across reasoning, tool-use, and coding benchmarks, AGS improves over its non-evolving configuration, and repeated reasoning runs report the accompanying output-token cost. Execution cases show a shared update lifecycle across all five resource types.