# Deep Learning for Sequential Decision Making under Uncertainty: Foundations, Frameworks, and Frontiers

arXiv: https://arxiv.org/abs/2604.11507 · HTML: https://mlsanity.com/paper/2604.11507/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 69 of its 161 references that are in the map.
- First posted on arXiv 13 Apr 2026.

## Builds on (most cited first, 30 of 69)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [Semi-Supervised Classification with Graph Convolutional Networks](https://mlsanity.com/paper/1609.02907/) (2016)
- [A Unified Approach to Interpreting Model Predictions](https://mlsanity.com/paper/1705.07874/) (2017)
- [Inductive Representation Learning on Large Graphs](https://mlsanity.com/paper/1706.02216/) (2017)
- ["Why Should I Trust You?": Explaining the Predictions of Any Classifier](https://mlsanity.com/paper/1602.04938/) (2016)
- [Neural Machine Translation by Jointly Learning to Align and Translate](https://mlsanity.com/paper/1409.0473/) (2014)
- [Dropout as a Bayesian Approximation: Representing Model Uncertainty in Deep Learning](https://mlsanity.com/paper/1506.02142/) (2015)
- [Simple and Scalable Predictive Uncertainty Estimation using Deep Ensembles](https://mlsanity.com/paper/1612.01474/) (2016)
- [Sequence to Sequence Learning with Neural Networks](https://mlsanity.com/paper/1409.3215/) (2014)
- [A Comprehensive Survey on Graph Neural Networks](https://mlsanity.com/paper/1901.00596/) (2019)
- [What Uncertainties Do We Need in Bayesian Deep Learning for Computer Vision?](https://mlsanity.com/paper/1703.04977/) (2017)
- [Offline Reinforcement Learning: Tutorial, Review, and Perspectives on Open Problems](https://mlsanity.com/paper/2005.01643/) (2020)
- [WaveNet: A Generative Model for Raw Audio](https://mlsanity.com/paper/1609.03499/) (2016)
- [Decision Transformer: Reinforcement Learning via Sequence Modeling](https://mlsanity.com/paper/2106.01345/) (2021)
- [An Empirical Evaluation of Generic Convolutional and Recurrent Networks for Sequence Modeling](https://mlsanity.com/paper/1803.01271/) (2018)
- [Distributionally Robust Neural Networks for Group Shifts: On the Importance of Regularization for Worst-Case Generalization](https://mlsanity.com/paper/1911.08731/) (2019)
- [Effective Approaches to Attention-based Neural Machine Translation](https://mlsanity.com/paper/1508.04025/) (2015)
- [Constrained Policy Optimization](https://mlsanity.com/paper/1705.10528/) (2017)
- [Pointer Networks](https://mlsanity.com/paper/1506.03134/) (2015)
- [A Tutorial on Bayesian Optimization](https://mlsanity.com/paper/1807.02811/) (2018)
- [Attention, Learn to Solve Routing Problems!](https://mlsanity.com/paper/1803.08475/) (2018)
- [Machine Learning for Combinatorial Optimization: a Methodological Tour d'Horizon](https://mlsanity.com/paper/1811.06128/) (2018)
- [Neural Combinatorial Optimization with Reinforcement Learning](https://mlsanity.com/paper/1611.09940/) (2016)
- [OptNet: Differentiable Optimization as a Layer in Neural Networks](https://mlsanity.com/paper/1703.00443/) (2017)
- [Multi-Agent Reinforcement Learning: A Selective Overview of Theories and Algorithms](https://mlsanity.com/paper/1911.10635/) (2019)
- [Learning Combinatorial Optimization Algorithms over Graphs](https://mlsanity.com/paper/1704.01665/) (2017)
- [Deep Recurrent Q-Learning for Partially Observable MDPs](https://mlsanity.com/paper/1507.06527/) (2015)
- [Differentiable Convex Optimization Layers](https://mlsanity.com/paper/1910.12430/) (2019)
- [Certifying Some Distributional Robustness with Principled Adversarial Training](https://mlsanity.com/paper/1710.10571/) (2017)

## Abstract (arXiv)

Artificial intelligence (AI) is moving increasingly beyond prediction to support decisions in complex, uncertain, and dynamic environments. This shift creates a natural intersection with operations research and management science (OR/MS), which has long provided methodological foundations for sequential decision making under uncertainty. At the same time, deep learning advances, including feedforward neural networks, recurrent architectures, transformers, large language models (LLMs), and deep reinforcement learning, have expanded data-driven modeling for large-scale decisions. This tutorial presents an OR/MS-centered perspective on deep learning for sequential decision making under uncertainty, bridging neural architectures and OR/MS approaches to decision making. Its premise: deep learning complements optimization rather than replacing it. Deep learning brings adaptability and scalable approximation, whereas OR/MS provides the mathematical rigor to represent constraints, recourse, uncertainty, and decision quality. The tutorial reviews key decision making foundations, connects them to the major neural architectures in modern AI, and organizes the field around three central themes: predict-then-optimize and decision-aware learning, learning-based decision generation under constraints for continuous and discrete problems with temporal coupling, and deep reinforcement learning for sequential and combinatorial decision making. Impact spans supply chains, service systems, healthcare and epidemic response, agriculture, energy, environmental sustainability, and autonomous operations. This tutorial frames these developments as part of a shift from predictive AI toward decision-capable AI, highlighting OR/MS's role in shaping the next generation of integrated learning--optimization systems.