# FGML-DG: Feynman-Inspired Cognitive Science Paradigm for Cross-Domain Medical Image Segmentation

arXiv: https://arxiv.org/abs/2604.10524 · HTML: https://mlsanity.com/paper/2604.10524/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 26 of its 43 references that are in the map.
- First posted on arXiv 12 Apr 2026.

## Builds on (most cited first, 26 of 26)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Arbitrary Style Transfer in Real-time with Adaptive Instance Normalization](https://mlsanity.com/paper/1703.06868/) (2017)
- [Improved Regularization of Convolutional Neural Networks with Cutout](https://mlsanity.com/paper/1708.04552/) (2017)
- [Domain Generalization with MixStyle](https://mlsanity.com/paper/2104.02008/) (2021)
- [Domain Generalization via Model-Agnostic Learning of Semantic Features](https://mlsanity.com/paper/1910.13580/) (2019)
- [CHAOS Challenge -- Combined (CT-MR) Healthy Abdominal Organ Segmentation](https://mlsanity.com/paper/2001.06535/) (2020)
- [FedDG: Federated Domain Generalization on Medical Image Segmentation via Episodic Learning in Continuous Frequency Space](https://mlsanity.com/paper/2103.06030/) (2021)
- [Robust and Generalizable Visual Representation Learning via Random Convolutions](https://mlsanity.com/paper/2007.13003/) (2020)
- [Shape-aware Meta-learning for Generalizing Prostate MRI Segmentation to Unseen Domains](https://mlsanity.com/paper/2007.02035/) (2020)
- [Causality-inspired Single-source Domain Generalization for Medical Image Segmentation](https://mlsanity.com/paper/2111.12525/) (2021)
- [Open Domain Generalization with Domain-Augmented Meta-Learning](https://mlsanity.com/paper/2104.03620/) (2021)
- [MixStyle Neural Networks for Domain Generalization and Adaptation](https://mlsanity.com/paper/2107.02053/) (2021)
- [Meta-DMoE: Adapting to Domain Shift by Meta-Distillation from Mixture-of-Experts](https://mlsanity.com/paper/2210.03885/) (2022)
- [Domain Generalization for Medical Image Analysis: A Review](https://mlsanity.com/paper/2310.08598/) (2023)
- [Generalizable Cross-modality Medical Image Segmentation via Style Augmentation and Dual Normalization](https://mlsanity.com/paper/2112.11177/) (2021)
- [Rethinking Data Augmentation for Single-source Domain Generalization in Medical Image Segmentation](https://mlsanity.com/paper/2211.14805/) (2022)
- [Semi-supervised Meta-learning with Disentanglement for Domain-generalised Medical Image Segmentation](https://mlsanity.com/paper/2106.13292/) (2021)
- [Domain Generalization on Medical Imaging Classification using Episodic Training with Task Augmentation](https://mlsanity.com/paper/2106.06908/) (2021)
- [MaxStyle: Adversarial Style Composition for Robust Medical Image Segmentation](https://mlsanity.com/paper/2206.01737/) (2022)
- [Adversarial Bayesian Augmentation for Single-Source Domain Generalization](https://mlsanity.com/paper/2307.09520/) (2023)
- [Domain Generalizer: A Few-shot Meta Learning Framework for Domain Generalization in Medical Imaging](https://mlsanity.com/paper/2008.07724/) (2020)
- [AdvST: Revisiting Data Augmentations for Single Domain Generalization](https://mlsanity.com/paper/2312.12720/) (2023)
- [StyDeSty: Min-Max Stylization and Destylization for Single Domain Generalization](https://mlsanity.com/paper/2406.00275/) (2024)
- [On-Device Domain Generalization](https://mlsanity.com/paper/2209.07521/) (2022)
- [Multi-Domain Learning by Meta-Learning: Taking Optimal Steps in Multi-Domain Loss Landscapes by Inner-Loop Learning](https://mlsanity.com/paper/2102.13147/) (2021)
- [Advancing Perception in Artificial Intelligence through Principles of Cognitive Science](https://mlsanity.com/paper/2310.08803/) (2023)

## Abstract (arXiv)

In medical image segmentation across multiple modalities (e.g., MRI, CT, etc.) and heterogeneous data sources (e.g., different hospitals and devices), Domain Generalization (DG) remains a critical challenge in AI-driven healthcare. This challenge primarily arises from domain shifts, imaging variations, and patient diversity, which often lead to degraded model performance in unseen domains. To address these limitations, we identify key issues in existing methods, including insufficient simplification of complex style features, inadequate reuse of domain knowledge, and a lack of feedback-driven optimization. To tackle these problems, inspired by Feynman's learning techniques in educational psychology, this paper introduces a cognitive science-inspired meta-learning paradigm for medical image domain generalization segmentation. We propose, for the first time, a cognitive-inspired Feynman-Guided Meta-Learning framework for medical image domain generalization segmentation (FGML-DG), which mimics human cognitive learning processes to enhance model learning and knowledge transfer. Specifically, we first leverage the 'concept understanding' principle from Feynman's learning method to simplify complex features across domains into style information statistics, achieving precise style feature alignment. Second, we design a meta-style memory and recall method (MetaStyle) to emulate the human memory system's utilization of past knowledge. Finally, we incorporate a Feedback-Driven Re-Training strategy (FDRT), which mimics Feynman's emphasis on targeted relearning, enabling the model to dynamically adjust learning focus based on prediction errors. Experimental results demonstrate that our method outperforms other existing domain generalization approaches on two challenging medical image domain generalization tasks.