# EviCare: Enhancing Diagnosis Prediction with Deep Model-Guided Evidence for In-Context Reasoning

arXiv: https://arxiv.org/abs/2604.10455 · HTML: https://mlsanity.com/paper/2604.10455/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning.
- Builds on 9 of its 42 references that are in the map.
- First posted on arXiv 12 Apr 2026.

## Placed in

- LLM reasoning / [Clinical and biomedical applications](https://mlsanity.com/lr/clinical-and-biomedical-applications/)

## Builds on (most cited first, 9 of 9)

- [Qwen3 Technical Report](https://mlsanity.com/paper/2505.09388/) (2025)
- [Self-Consistency Improves Chain of Thought Reasoning in Language Models](https://mlsanity.com/paper/2203.11171/) (2022)
- [Capabilities of GPT-4 on Medical Challenge Problems](https://mlsanity.com/paper/2303.13375/) (2023)
- [Evaluating GPT-4 and ChatGPT on Japanese Medical Licensing Examinations](https://mlsanity.com/paper/2303.18027/) (2023)
- [GraphCare: Enhancing Healthcare Predictions with Personalized Knowledge Graphs](https://mlsanity.com/paper/2305.12788/) (2023)
- [Reasoning-Enhanced Healthcare Predictions with Knowledge Graph Community Retrieval](https://mlsanity.com/paper/2410.04585/) (2024)
- [Enough Coin Flips Can Make LLMs Act Bayesian](https://mlsanity.com/paper/2503.04722/) (2025)
- [Health-LLM: Personalized Retrieval-Augmented Disease Prediction System](https://mlsanity.com/paper/2402.00746/) (2024)
- [A Survey on Large Language Models from General Purpose to Medical Applications: Datasets, Methodologies, and Evaluations](https://mlsanity.com/paper/2406.10303/) (2024)

## Abstract (arXiv)

Recent advances in large language models (LLMs) have enabled promising progress in diagnosis prediction from electronic health records (EHRs). However, existing LLM-based approaches tend to overfit to historically observed diagnoses, often overlooking novel yet clinically important conditions that are critical for early intervention. To address this, we propose EviCare, an in-context reasoning framework that integrates deep model guidance into LLM-based diagnosis prediction. Rather than prompting LLMs directly with raw EHR inputs, EviCare performs (1) deep model inference for candidate selection, (2) evidential prioritization for set-based EHRs, and (3) relational evidence construction for novel diagnosis prediction. These signals are then composed into an adaptive in-context prompt to guide LLM reasoning in an accurate and interpretable manner. Extensive experiments on two real-world EHR benchmarks (MIMIC-III and MIMIC-IV) demonstrate that EviCare achieves significant performance gains, which consistently outperforms both LLM-only and deep model-only baselines by an average of 20.65% across precision and accuracy metrics. The improvements are particularly notable in challenging novel diagnosis prediction, yielding average improvements of 30.97%.