# Active Diffusion Matching: Score-based Iterative Alignment of Cross-Modal Retinal Images

arXiv: https://arxiv.org/abs/2604.10084 · HTML: https://mlsanity.com/paper/2604.10084/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 49 of its 84 references that are in the map.
- First posted on arXiv 11 Apr 2026.

## Builds on (most cited first, 30 of 49)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [Scalable Diffusion Models with Transformers](https://mlsanity.com/paper/2212.09748/) (2022)
- [Generative Modeling by Estimating Gradients of the Data Distribution](https://mlsanity.com/paper/1907.05600/) (2019)
- [Benchmarking Neural Network Robustness to Common Corruptions and Perturbations](https://mlsanity.com/paper/1903.12261/) (2019)
- [Photo-Realistic Single Image Super-Resolution Using a Generative Adversarial Network](https://mlsanity.com/paper/1609.04802/) (2016)
- [Consistency Models](https://mlsanity.com/paper/2303.01469/) (2023)
- [Enhanced Deep Residual Networks for Single Image Super-Resolution](https://mlsanity.com/paper/1707.02921/) (2017)
- [SuperGlue: Learning Feature Matching with Graph Neural Networks](https://mlsanity.com/paper/1911.11763/) (2019)
- [Spatial Transformer Networks](https://mlsanity.com/paper/1506.02025/) (2015)
- [Beyond a Gaussian Denoiser: Residual Learning of Deep CNN for Image Denoising](https://mlsanity.com/paper/1608.03981/) (2016)
- [SuperPoint: Self-Supervised Interest Point Detection and Description](https://mlsanity.com/paper/1712.07629/) (2017)
- [LoFTR: Detector-Free Local Feature Matching with Transformers](https://mlsanity.com/paper/2104.00680/) (2021)
- [CvT: Introducing Convolutions to Vision Transformers](https://mlsanity.com/paper/2103.15808/) (2021)
- [On Distillation of Guided Diffusion Models](https://mlsanity.com/paper/2210.03142/) (2022)
- [VoxelMorph: A Learning Framework for Deformable Medical Image Registration](https://mlsanity.com/paper/1809.05231/) (2018)
- [LightGlue: Local Feature Matching at Light Speed](https://mlsanity.com/paper/2306.13643/) (2023)
- [Learning to See in the Dark](https://mlsanity.com/paper/1805.01934/) (2018)
- [GMFlow: Learning Optical Flow via Global Matching](https://mlsanity.com/paper/2111.13680/) (2021)
- [FlowFormer: A Transformer Architecture for Optical Flow](https://mlsanity.com/paper/2203.16194/) (2022)
- [R2D2: Repeatable and Reliable Detector and Descriptor](https://mlsanity.com/paper/1906.06195/) (2019)
- [DKM: Dense Kernelized Feature Matching for Geometry Estimation](https://mlsanity.com/paper/2202.00667/) (2022)
- [ASpanFormer: Detector-Free Image Matching with Adaptive Span Transformer](https://mlsanity.com/paper/2208.14201/) (2022)
- [A Deep Learning Framework for Unsupervised Affine and Deformable Image Registration](https://mlsanity.com/paper/1809.06130/) (2018)
- [An Unsupervised Learning Model for Deformable Medical Image Registration](https://mlsanity.com/paper/1802.02604/) (2018)

## Abstract (arXiv)

Objective: The study aims to address the challenge of aligning Standard Fundus Images (SFIs) and Ultra-Widefield Fundus Images (UWFIs), which is difficult due to their substantial differences in viewing range and the amorphous appearance of the retina. Currently, no specialized method exists for this task, and existing image alignment techniques lack accuracy. Methods: We propose Active Diffusion Matching (ADM), a novel cross-modal alignment method. ADM integrates two interdependent score-based diffusion models to jointly estimate global transformations and local deformations via an iterative Langevin Markov chain. This approach facilitates a stochastic, progressive search for optimal alignment. Additionally, custom sampling strategies are introduced to enhance the adaptability of ADM to given input image pairs. Results: Comparative experimental evaluations demonstrate that ADM achieves state-of-the-art alignment accuracy. This was validated on two datasets: a private dataset of SFI-UWFI pairs and a public dataset of SFI-SFI pairs, with mAUC improvements of 5.2 and 0.4 points on the private and public datasets, respectively, compared to existing state-of-the-art methods. Conclusion: ADM effectively bridges the gap in aligning SFIs and UWFIs, providing an innovative solution to a previously unaddressed challenge. The method's ability to jointly optimize global and local alignment makes it highly effective for cross-modal image alignment tasks. Significance: ADM has the potential to transform the integrated analysis of SFIs and UWFIs, enabling better clinical utility and supporting learning-based image enhancements. This advancement could significantly improve diagnostic accuracy and patient outcomes in ophthalmology.