# RABC-Net: Reliability-Aware Annotation-Free Skin Lesion Segmentation for Low-Resource Dermoscopy

arXiv: https://arxiv.org/abs/2604.05594 · HTML: https://mlsanity.com/paper/2604.05594/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 10 of its 25 references that are in the map.
- First posted on arXiv 7 Apr 2026.

## Builds on (most cited first, 10 of 10)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [Skin Lesion Analysis Toward Melanoma Detection 2018: A Challenge Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1902.03368/) (2019)
- [Skin Lesion Analysis Toward Melanoma Detection: A Challenge at the 2017 International Symposium on Biomedical Imaging (ISBI), Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1710.05006/) (2017)
- [TransFuse: Fusing Transformers and CNNs for Medical Image Segmentation](https://mlsanity.com/paper/2102.08005/) (2021)
- [Shape-aware Meta-learning for Generalizing Prostate MRI Segmentation to Unseen Domains](https://mlsanity.com/paper/2007.02035/) (2020)
- [Synergistic Image and Feature Adaptation: Towards Cross-Modality Domain Adaptation for Medical Image Segmentation](https://mlsanity.com/paper/1901.08211/) (2019)
- [Test-Time Adaptable Neural Networks for Robust Medical Image Segmentation](https://mlsanity.com/paper/2004.04668/) (2020)
- [Unsupervised Skin Lesion Segmentation via Structural Entropy Minimization on Multi-Scale Superpixel Graphs](https://mlsanity.com/paper/2309.01899/) (2023)
- [Automatic skin lesion segmentation on dermoscopic images by the means of superpixel merging](https://mlsanity.com/paper/1808.06759/) (2018)

## Abstract (arXiv)

Pixel-level annotation is costly in low-resource dermoscopy. We present RABC-Net, a reliability-aware annotation-free segmentation system that combines pseudo-label reliability learning, restricted target-domain adaptation, and Reliability-Adaptive Boundary Calibration (RABC). The system decouples reliability learning from deployment: uncertainty-aware pseudo-label interaction shapes robust representations during training, while the image-only inference path is preserved and RABC performs local logit-space calibration from boundary confidence, uncertainty, and foreground probability. No manual masks are used for training or target-domain adaptation; validation labels, when available, are used only for final operating-point selection. Across ISIC-2017, ISIC-2018, and PH2, RABC-Net achieves macro-average DICE/JAC of 86.58%/79.47% and consistent matched-protocol results. Controlled within-study analyses show that RABC provides localized gains over nonlearned boundary correction, while the overall result comes from the full reliability-aware system. Adaptation updates only 3.50% of model parameters, image-only inference runs at 87.4 FPS, and the selected operating points use σ=0 on all three datasets, indicating that learned calibration avoids extra smoothing at deployment.