# 3D Gaussian Splatting for Annular Dark Field Scanning Transmission Electron Microscopy Tomography Reconstruction

arXiv: https://arxiv.org/abs/2604.04693 · HTML: https://mlsanity.com/paper/2604.04693/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 14 of its 42 references that are in the map.
- First posted on arXiv 6 Apr 2026.

## Builds on (most cited first, 14 of 14)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [3D Gaussian Splatting for Real-Time Radiance Field Rendering](https://mlsanity.com/paper/2308.04079/) (2023)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [4D Gaussian Splatting for Real-Time Dynamic Scene Rendering](https://mlsanity.com/paper/2310.08528/) (2023)
- [DreamGaussian: Generative Gaussian Splatting for Efficient 3D Content Creation](https://mlsanity.com/paper/2309.16653/) (2023)
- [HUGS: Human Gaussian Splats](https://mlsanity.com/paper/2311.17910/) (2023)
- [NAF: Neural Attenuation Fields for Sparse-View CBCT Reconstruction](https://mlsanity.com/paper/2209.14540/) (2022)
- [Human Gaussian Splatting: Real-time Rendering of Animatable Avatars](https://mlsanity.com/paper/2311.17113/) (2023)
- [DreamScene: 3D Gaussian-based Text-to-3D Scene Generation via Formation Pattern Sampling](https://mlsanity.com/paper/2404.03575/) (2024)
- [R2-Gaussian: Rectifying Radiative Gaussian Splatting for Tomographic Reconstruction](https://mlsanity.com/paper/2405.20693/) (2024)
- [SplatPose+: Real-time Image-Based Pose-Agnostic 3D Anomaly Detection](https://mlsanity.com/paper/2410.12080/) (2024)
- [X2-Gaussian: 4D Radiative Gaussian Splatting for Continuous-time Tomographic Reconstruction](https://mlsanity.com/paper/2503.21779/) (2025)
- [GaRField++: Reinforced Gaussian Radiance Fields for Large-Scale 3D Scene Reconstruction](https://mlsanity.com/paper/2409.12774/) (2024)
- [GEM: 3D Gaussian Splatting for Efficient and Accurate Cryo-EM Reconstruction](https://mlsanity.com/paper/2509.25075/) (2025)

## Built on by (most cited first, 1 of 1)

- [NanoMorph-3D: An End-to-End Physics-Driven Unrolling Framework for Nanomaterial Reconstruction](https://mlsanity.com/paper/2608.03257/) (2026)

## Abstract (arXiv)

Analytical Dark Field Scanning Transmission Electron Microscopy (ADF-STEM) tomography reconstructs nanoscale materials in 3D by integrating multi-view tilt-series images, enabling precise analysis of their structural and compositional features. Although integrating more tilt views improves 3D reconstruction, it requires extended electron exposure that risks damaging dose-sensitive materials and introduces drift and misalignment, making it difficult to balance reconstruction fidelity with sample preservation. In practice, sparse-view acquisition is frequently required, yet conventional ADF-STEM methods degrade under limited views, exhibiting artifacts and reduced structural fidelity. To resolve these issues, in this paper, we adapt 3D GS to this domain with three key components. We first model the local scattering strength as a learnable scalar field, denza, to address the mismatch between 3DGS and ADF-STEM imaging physics. Then we introduce a coefficient γ to stabilize scattering across tilt angles, ensuring consistent denza via scattering view normalization. Finally, We incorporate a loss function that includes a 2D Fourier amplitude term to suppress missing wedge artifacts in sparse-view reconstruction. Experiments on 45-view and 15-view tilt series show that DenZa-Gaussian produces high-fidelity reconstructions and 2D projections that align more closely with original tilts, demonstrating superior robustness under sparse-view conditions.