# DenOiS: Dual-Domain Denoising of Observation and Solution in Ultrasound Image Reconstruction

arXiv: https://arxiv.org/abs/2604.02105 · HTML: https://mlsanity.com/paper/2604.02105/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 17 of its 34 references that are in the map.
- First posted on arXiv 2 Apr 2026.

## Builds on (most cited first, 17 of 17)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Beyond a Gaussian Denoiser: Residual Learning of Deep CNN for Image Denoising](https://mlsanity.com/paper/1608.03981/) (2016)
- [Plug-and-Play Image Restoration with Deep Denoiser Prior](https://mlsanity.com/paper/2008.13751/) (2020)
- [Deep Convolutional Neural Network for Inverse Problems in Imaging](https://mlsanity.com/paper/1611.03679/) (2016)
- [Learning Deep CNN Denoiser Prior for Image Restoration](https://mlsanity.com/paper/1704.03264/) (2017)
- [MoDL: Model Based Deep Learning Architecture for Inverse Problems](https://mlsanity.com/paper/1712.02862/) (2017)
- [Learning a Variational Network for Reconstruction of Accelerated MRI Data](https://mlsanity.com/paper/1704.00447/) (2017)
- [Denoising Diffusion Models for Plug-and-Play Image Restoration](https://mlsanity.com/paper/2305.08995/) (2023)
- [Learned Primal-dual Reconstruction](https://mlsanity.com/paper/1707.06474/) (2017)
- [Image reconstruction by domain transform manifold learning](https://mlsanity.com/paper/1704.08841/) (2017)
- [DOLCE: A Model-Based Probabilistic Diffusion Framework for Limited-Angle CT Reconstruction](https://mlsanity.com/paper/2211.12340/) (2022)
- [Image Reconstruction: From Sparsity to Data-adaptive Methods and Machine Learning](https://mlsanity.com/paper/1904.02816/) (2019)
- [Deep Variational Networks with Exponential Weighting for Learning Computed Tomography](https://mlsanity.com/paper/1906.05528/) (2019)
- [Learning the Imaging Model of Speed-of-Sound Reconstruction via a Convolutional Formulation](https://mlsanity.com/paper/2309.00453/) (2023)

## Abstract (arXiv)

Medical imaging aims to recover underlying tissue properties, using inexact (simplified/linearized) imaging models and often from inaccurate and incomplete measurements. Analytical reconstruction methods rely on hand-crafted regularization, sensitive to noise assumptions and parameter tuning. Among deep learning alternatives, plug-and-play (PnP) approaches learn regularization while incorporating imaging physics during inference, outperforming purely data-driven methods. The performance of all these approaches, however, still strongly depends on measurement quality and imaging model accuracy. In this work, we propose DenOiS, a framework that denoises both input observations and resulting solution in their respective domains. It consists of an observation refinement strategy that corrects degraded measurements while compensating for imaging model simplifications, and a diffusion-based PnP reconstruction approach that remains robust under missing measurements. DenOiS enables generalization to real data from training only in simulations, resulting in high-fidelity image reconstruction with noisy observations and inexact imaging models. We demonstrate this for speed-of-sound imaging as a challenging setting of quantitative ultrasound image reconstruction.