# Care-Conditioned Neuromodulation for Autonomy-Preserving Supportive Dialogue Agents

arXiv: https://arxiv.org/abs/2604.01576 · HTML: https://mlsanity.com/paper/2604.01576/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in General LLM agent frameworks and benchmarks, one of 16 directions in LLM agents and tool use.
- Builds on 15 of its 23 references that are in the map.
- First posted on arXiv 2 Apr 2026.

## Placed in

- LLM agents and tool use / [General LLM agent frameworks and benchmarks](https://mlsanity.com/agents/general-llm-agent-frameworks-and-benchmarks/)

## Builds on (most cited first, 15 of 15)

- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
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- [Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks](https://mlsanity.com/paper/2005.11401/) (2020)
- [Direct Preference Optimization: Your Language Model is Secretly a Reward Model](https://mlsanity.com/paper/2305.18290/) (2023)
- [QLoRA: Efficient Finetuning of Quantized LLMs](https://mlsanity.com/paper/2305.14314/) (2023)
- [Constitutional AI: Harmlessness from AI Feedback](https://mlsanity.com/paper/2212.08073/) (2022)
- [Personalizing Dialogue Agents: I have a dog, do you have pets too?](https://mlsanity.com/paper/1801.07243/) (2018)
- [Plug and Play Language Models: A Simple Approach to Controlled Text Generation](https://mlsanity.com/paper/1912.02164/) (2019)
- [Compacter: Efficient Low-Rank Hypercomplex Adapter Layers](https://mlsanity.com/paper/2106.04647/) (2021)
- [Memory Networks](https://mlsanity.com/paper/1410.3916/) (2014)
- [Towards Emotional Support Dialog Systems](https://mlsanity.com/paper/2106.01144/) (2021)
- [Beyond Goldfish Memory: Long-Term Open-Domain Conversation](https://mlsanity.com/paper/2107.07567/) (2021)
- [NeuroLogic Decoding: (Un)supervised Neural Text Generation with Predicate Logic Constraints](https://mlsanity.com/paper/2010.12884/) (2020)
- [Can You Put it All Together: Evaluating Conversational Agents' Ability to Blend Skills](https://mlsanity.com/paper/2004.08449/) (2020)
- [MIME: MIMicking Emotions for Empathetic Response Generation](https://mlsanity.com/paper/2010.01454/) (2020)

## Abstract (arXiv)

Large language models deployed in supportive or advisory roles must balance helpfulness with preservation of user autonomy, yet standard alignment methods primarily optimize for helpfulness and harmlessness without explicitly modeling relational risks such as dependency reinforcement, overprotection, or coercive guidance. We introduce Care-Conditioned Neuromodulation (CCN), a state-dependent control framework in which a learned scalar signal derived from structured user state and dialogue context conditions response generation and candidate selection. We formalize this setting as an autonomy-preserving alignment problem and define a utility function that rewards autonomy support and helpfulness while penalizing dependency and coercion. We also construct a benchmark of relational failure modes in multi-turn dialogue, including reassurance dependence, manipulative care, overprotection, and boundary inconsistency. On this benchmark, care-conditioned candidate generation combined with utility-based reranking improves autonomy-preserving utility by +0.25 over supervised fine-tuning and +0.07 over preference optimization baselines while maintaining comparable supportiveness. Pilot human evaluation and zero-shot transfer to real emotional-support conversations show directional agreement with automated metrics. These results suggest that state-dependent control combined with utility-based selection is a practical approach to multi-objective alignment in autonomy-sensitive dialogue.