# Cross-Domain Vessel Segmentation via Latent Similarity Mining and Iterative Co-Optimization

arXiv: https://arxiv.org/abs/2604.01553 · HTML: https://mlsanity.com/paper/2604.01553/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 13 of its 20 references that are in the map.
- First posted on arXiv 2 Apr 2026.

## Builds on (most cited first, 13 of 13)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Improved Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2102.09672/) (2021)
- [Diffusion Autoencoders: Toward a Meaningful and Decodable Representation](https://mlsanity.com/paper/2111.15640/) (2021)
- [SePiCo: Semantic-Guided Pixel Contrast for Domain Adaptive Semantic Segmentation](https://mlsanity.com/paper/2204.08808/) (2022)
- [ROSE: A Retinal OCT-Angiography Vessel Segmentation Dataset and New Model](https://mlsanity.com/paper/2007.05201/) (2020)
- [Deep Symmetric Adaptation Network for Cross-modality Medical Image Segmentation](https://mlsanity.com/paper/2101.06853/) (2021)
- [AADG: Automatic Augmentation for Domain Generalization on Retinal Image Segmentation](https://mlsanity.com/paper/2207.13249/) (2022)
- [One-Shot Structure-Aware Stylized Image Synthesis](https://mlsanity.com/paper/2402.17275/) (2024)
- [FPL+: Filtered Pseudo Label-based Unsupervised Cross-Modality Adaptation for 3D Medical Image Segmentation](https://mlsanity.com/paper/2404.04971/) (2024)
- [A Chebyshev Confidence Guided Source-Free Domain Adaptation Framework for Medical Image Segmentation](https://mlsanity.com/paper/2310.18087/) (2023)

## Abstract (arXiv)

Retinal vessel segmentation serves as a critical prerequisite for automated diagnosis of retinal pathologies. While recent advances in Convolutional Neural Networks (CNNs) have demonstrated promising performance in this task, significant performance degradation occurs when domain shifts exist between training and testing data. To address these limitations, we propose a novel domain transfer framework that leverages latent vascular similarity across domains and iterative co-optimization of generation and segmentation networks. Specifically, we first pre-train generation networks for source and target domains. Subsequently, the pretrained source-domain conditional diffusion model performs deterministic inversion to establish intermediate latent representations of vascular images, creating domain-agnostic prototypes for target synthesis. Finally, we develop an iterative refinement strategy where segmentation network and generative model undergo mutual optimization through cyclic parameter updating. This co-evolution process enables simultaneous enhancement of cross-domain image synthesis quality and segmentation accuracy. Experiments demonstrate that our framework achieves state-of-the-art performance in cross-domain retinal vessel segmentation, particularly in challenging clinical scenarios with significant modality discrepancies.