# A Safety-Aware Role-Orchestrated Multi-Agent LLM Framework for Behavioral Health Communication Simulation

arXiv: https://arxiv.org/abs/2604.00249 · HTML: https://mlsanity.com/paper/2604.00249/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Medical and scientific domain agents, one of 16 directions in LLM agents and tool use.
- Builds on 12 of its 22 references that are in the map.
- First posted on arXiv 31 Mar 2026.

## Placed in

- LLM agents and tool use / [Medical and scientific domain agents](https://mlsanity.com/agents/medical-and-scientific-domain-agents/)

## Builds on (most cited first, 12 of 12)

- [Generative Agents: Interactive Simulacra of Human Behavior](https://mlsanity.com/paper/2304.03442/) (2023)
- [AutoGen: Enabling Next-Gen LLM Applications via Multi-Agent Conversation](https://mlsanity.com/paper/2308.08155/) (2023)
- [Prompt Programming for Large Language Models: Beyond the Few-Shot Paradigm](https://mlsanity.com/paper/2102.07350/) (2021)
- [MedAgents: Large Language Models as Collaborators for Zero-shot Medical Reasoning](https://mlsanity.com/paper/2311.10537/) (2023)
- [Towards Interpretable Mental Health Analysis with Large Language Models](https://mlsanity.com/paper/2304.03347/) (2023)
- [Optima: Optimizing Effectiveness and Efficiency for LLM-Based Multi-Agent System](https://mlsanity.com/paper/2410.08115/) (2024)
- [Utilizing Neural Networks and Linguistic Metadata for Early Detection of Depression Indications in Text Sequences](https://mlsanity.com/paper/1804.07000/) (2018)
- [OSC: Cognitive Orchestration through Dynamic Knowledge Alignment in Multi-Agent LLM Collaboration](https://mlsanity.com/paper/2509.04876/) (2025)
- [Beyond Direct Diagnosis: LLM-based Multi-Specialist Agent Consultation for Automatic Diagnosis](https://mlsanity.com/paper/2401.16107/) (2024)
- [EmoAgent: Assessing and Safeguarding Human-AI Interaction for Mental Health Safety](https://mlsanity.com/paper/2504.09689/) (2025)
- [Script-Based Dialog Policy Planning for LLM-Powered Conversational Agents: A Basic Architecture for an "AI Therapist"](https://mlsanity.com/paper/2412.15242/) (2024)
- [Turn-Level Empathy Prediction Using Psychological Indicators](https://mlsanity.com/paper/2407.08607/) (2024)

## Built on by (most cited first, 1 of 1)

- [Can LLM Agents Sustain Long-Horizon Organizational Dynamics?](https://mlsanity.com/paper/2606.01199/) (2026)

## Abstract (arXiv)

Single-agent large language model (LLM) systems struggle to simultaneously support diverse conversational functions and maintain safety in behavioral health communication. We propose a safety-aware, role-orchestrated multi-agent LLM framework designed to simulate supportive behavioral health dialogue through coordinated, role-differentiated agents. Conversational responsibilities are decomposed across specialized agents, including empathy-focused, action-oriented, and supervisory roles, while a prompt-based controller dynamically activates relevant agents and enforces continuous safety auditing. Using semi-structured interview transcripts from the DAIC-WOZ corpus, we evaluate the framework with scalable proxy metrics capturing structural quality, functional diversity, and computational characteristics. Results illustrate clear role differentiation, coherent inter-agent coordination, and predictable trade-offs between modular orchestration, safety oversight, and response latency when compared to a single-agent baseline. This work emphasizes system design, interpretability, and safety, positioning the framework as a simulation and analysis tool for behavioral health informatics and decision-support research rather than a clinical intervention.