# Architecting Secure AI Agents: Perspectives on System-Level Defenses Against Indirect Prompt Injection Attacks

arXiv: https://arxiv.org/abs/2603.30016 · HTML: https://mlsanity.com/paper/2603.30016/

## Key facts

- Cited by 9 papers in the map (data through 14 Oct 2026).
- Placed in Agent threats, guardrails and governance, one of 16 directions in LLM agents and tool use.
- Builds on 24 of its 32 references that are in the map.
- First posted on arXiv 31 Mar 2026.

## Placed in

- LLM agents and tool use / [Agent threats, guardrails and governance](https://mlsanity.com/agents/agent-threats-guardrails-and-governance/)
- LLM safety and security / [Prompt injection and agent security](https://mlsanity.com/safety/prompt-injection-and-agent-security/)

## Builds on (most cited first, 24 of 24)

- [Not what you've signed up for: Compromising Real-World LLM-Integrated Applications with Indirect Prompt Injection](https://mlsanity.com/paper/2302.12173/) (2023)
- [InjecAgent: Benchmarking Indirect Prompt Injections in Tool-Integrated Large Language Model Agents](https://mlsanity.com/paper/2403.02691/) (2024)
- [The Instruction Hierarchy: Training LLMs to Prioritize Privileged Instructions](https://mlsanity.com/paper/2404.13208/) (2024)
- [StruQ: Defending Against Prompt Injection with Structured Queries](https://mlsanity.com/paper/2402.06363/) (2024)
- [Agent Security Bench (ASB): Formalizing and Benchmarking Attacks and Defenses in LLM-based Agents](https://mlsanity.com/paper/2410.02644/) (2024)
- [Defeating Prompt Injections by Design](https://mlsanity.com/paper/2503.18813/) (2025)
- [Defending Against Indirect Prompt Injection Attacks With Spotlighting](https://mlsanity.com/paper/2403.14720/) (2024)
- [SecAlign: Defending Against Prompt Injection with Preference Optimization](https://mlsanity.com/paper/2410.05451/) (2024)
- [Progent: Securing AI Agents with Privilege Control](https://mlsanity.com/paper/2504.11703/) (2025)
- [The Attacker Moves Second: Stronger Adaptive Attacks Bypass Defenses Against Llm Jailbreaks and Prompt Injections](https://mlsanity.com/paper/2510.09023/) (2025)
- [PromptArmor: Simple yet Effective Prompt Injection Defenses](https://mlsanity.com/paper/2507.15219/) (2025)
- [Attention Tracker: Detecting Prompt Injection Attacks in LLMs](https://mlsanity.com/paper/2411.00348/) (2024)
- [Prompt Flow Integrity to Prevent Privilege Escalation in LLM Agents](https://mlsanity.com/paper/2503.15547/) (2025)
- [DRIFT: Dynamic Rule-Based Defense with Injection Isolation for Securing LLM Agents](https://mlsanity.com/paper/2506.12104/) (2025)
- [AgentDyn: Are Your Agent Security Defenses Deployable in Real-World Dynamic Environments?](https://mlsanity.com/paper/2602.03117/) (2026)
- [AgentArmor: Enforcing Program Analysis on Agent Runtime Trace to Defend Against Prompt Injection](https://mlsanity.com/paper/2508.01249/) (2025)
- [RL Is a Hammer and LLMs Are Nails: A Simple Reinforcement Learning Recipe for Strong Prompt Injection](https://mlsanity.com/paper/2510.04885/) (2025)
- [Cedar: A New Language for Expressive, Fast, Safe, and Analyzable Authorization (Extended Version)](https://mlsanity.com/paper/2403.04651/) (2024)
- [The Landscape of Prompt Injection Threats in LLM Agents: From Taxonomy to Analysis](https://mlsanity.com/paper/2602.10453/) (2026)
- [PIShield: Detecting Prompt Injection Attacks via Intrinsic LLM Features](https://mlsanity.com/paper/2510.14005/) (2025)
- [PISmith: Reinforcement Learning-based Red Teaming for Prompt Injection Defenses](https://mlsanity.com/paper/2603.13026/) (2026)
- [Systems Security Foundations for Agentic Computing](https://mlsanity.com/paper/2512.01295/) (2025)
- [Taxonomy, Evaluation and Exploitation of IPI-Centric LLM Agent Defense Frameworks](https://mlsanity.com/paper/2511.15203/) (2025)
- [Mitigating Indirect Prompt Injection via Instruction-Following Intent Analysis](https://mlsanity.com/paper/2512.00966/) (2025)

## Built on by (most cited first, 9 of 9)

- [Reframing LLM Agent Security as an Agent-Human Interaction Problem](https://mlsanity.com/paper/2605.24309/) (2026)
- [Trust No Tool: Evaluating and Defending LLM Agents under Untrusted Tool Feedback](https://mlsanity.com/paper/2605.17453/) (2026)
- [EvoSafeHarness: Evolving Model- and Domain-Specific Harnesses for Securing Agents](https://mlsanity.com/paper/2609.05903/) (2026)
- [Tiny Enough to Break In: Agentic Remote Access Trojans Powered by Small Language Models](https://mlsanity.com/paper/2608.03009/) (2026)
- [AgentAntibody: An Adaptive Immune System for Defending LLM Agents against Prompt Injection](https://mlsanity.com/paper/2608.04053/) (2026)
- [ActGov: Governing LLM Agent Actions via Policy-Constrained Validation](https://mlsanity.com/paper/2609.24446/) (2026)
- [Where Is the Tradeoff in Using Third-Party API Routers for Agentic Software Development?](https://mlsanity.com/paper/2607.23624/) (2026)
- [PromptShield Home: Ambient Multimodal Prompt Injection Defense for Smart-Home Agents](https://mlsanity.com/paper/2608.05495/) (2026)
- [Toward Metacognitive One-Shot Indirect Prompt Injection: Strategy Abstraction Via Outcome-Conditioned Reflection](https://mlsanity.com/paper/2608.08795/) (2026)

## Abstract (arXiv)

AI agents, predominantly powered by large language models (LLMs), are vulnerable to indirect prompt injection, in which malicious instructions embedded in untrusted data can trigger dangerous agent actions. This position paper discusses our vision for system-level defenses against indirect prompt injection attacks. We articulate three positions: (1) dynamic replanning and security policy updates are often necessary for dynamic tasks and realistic environments; (2) certain context-dependent security decisions would still require LLMs (or other learned models), but should only be made within system designs that strictly constrain what the model can observe and decide; (3) in inherently ambiguous cases, personalization and human interaction should be treated as core design considerations. In addition to our main positions, we discuss limitations of existing benchmarks that can create a false sense of utility and security. We also highlight the value of system-level defenses, which serve as the skeleton of agentic systems by structuring and controlling agent behaviors, integrating rule-based and model-based security checks, and enabling more targeted research on model robustness and human interaction.