# All-in-One Augmented Reality Guided Head and Neck Tumor Resection

arXiv: https://arxiv.org/abs/2603.29495 · HTML: https://mlsanity.com/paper/2603.29495/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 4 of its 17 references that are in the map.
- First posted on arXiv 31 Mar 2026.

## Builds on (most cited first, 4 of 4)

- [TEASER: Fast and Certifiable Point Cloud Registration](https://mlsanity.com/paper/2001.07715/) (2020)
- [Fast and Robust Iterative Closest Point](https://mlsanity.com/paper/2007.07627/) (2020)
- [STTAR: Surgical Tool Tracking using off-the-shelf Augmented Reality Head-Mounted Displays](https://mlsanity.com/paper/2208.08880/) (2022)
- [Markerless Augmented Reality Registration for Surgical Guidance: A Multi-Anatomy Clinical Accuracy Study](https://mlsanity.com/paper/2511.02086/) (2025)

## Built on by (most cited first, 2 of 2)

- [Marker-free deformable registration and fusion for augmented reality-guided positive margin localization during tumor resection surgery](https://mlsanity.com/paper/2607.13343/) (2026)
- [Toward surface-based registration of a virtual preoperative cutting guide onto the mandible for reconstruction surgery](https://mlsanity.com/paper/2608.06599/) (2026)

## Abstract (arXiv)

Positive margins are common in head and neck squamous cell carcinoma, yet intraoperative re-resection is often imprecise because margin locations are typically communicated verbally from pathology. We present an all-in-one augmented reality (AR) system that relocalizes positive margins from a resected specimen to the resection bed and visualizes them in situ using HoloLens 2 depth sensing and fully automated markerless surface registration. In a silicone phantom study with six medical trainees, markerless registration achieved target registration errors comparable to a marker-based baseline (median 1.8 mm vs. 1.7 mm; maximum < 4 mm). In a margin relocalization task, AR guidance reduced error from verbal guidance (median 14.2 mm) to a few millimeters (median 3.2 mm), with all AR localizations within 5 mm error. These results support the feasibility of markerless AR margin guidance for more precise intraoperative re-excision.