# Mimosa Framework: Toward Evolving Multi-Agent Systems for Scientific Research

arXiv: https://arxiv.org/abs/2603.28986 · HTML: https://mlsanity.com/paper/2603.28986/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Web, search, and research agents, one of 16 directions in LLM agents and tool use.
- Builds on 26 of its 83 references that are in the map.
- First posted on arXiv 30 Mar 2026.

## Placed in

- LLM agents and tool use / [Web, search, and research agents](https://mlsanity.com/agents/web-search-and-research-agents/)

## Builds on (most cited first, 26 of 26)

- [Judging LLM-as-a-Judge with MT-Bench and Chatbot Arena](https://mlsanity.com/paper/2306.05685/) (2023)
- [Lost in the Middle: How Language Models Use Long Contexts](https://mlsanity.com/paper/2307.03172/) (2023)
- [A Survey on LLM-as-a-Judge](https://mlsanity.com/paper/2411.15594/) (2024)
- [Towards Reasoning in Large Language Models: A Survey](https://mlsanity.com/paper/2212.10403/) (2022)
- [Executable Code Actions Elicit Better LLM Agents](https://mlsanity.com/paper/2402.01030/) (2024)
- [Promptbreeder: Self-Referential Self-Improvement Via Prompt Evolution](https://mlsanity.com/paper/2309.16797/) (2023)
- [The AI Scientist-v2: Workshop-Level Automated Scientific Discovery via Agentic Tree Search](https://mlsanity.com/paper/2504.08066/) (2025)
- [MLAgentBench: Evaluating Language Agents on Machine Learning Experimentation](https://mlsanity.com/paper/2310.03302/) (2023)
- [Darwin Godel Machine: Open-Ended Evolution of Self-Improving Agents](https://mlsanity.com/paper/2505.22954/) (2025)
- [AgentSquare: Automatic LLM Agent Search in Modular Design Space](https://mlsanity.com/paper/2410.06153/) (2024)
- [Towards a Science of Scaling Agent Systems](https://mlsanity.com/paper/2512.08296/) (2025)
- [EvoAgent: Towards Automatic Multi-Agent Generation via Evolutionary Algorithms](https://mlsanity.com/paper/2406.14228/) (2024)
- [BixBench: a Comprehensive Benchmark for LLM-based Agents in Computational Biology](https://mlsanity.com/paper/2503.00096/) (2025)
- [Lifelong Learning of Large Language Model based Agents: A Roadmap](https://mlsanity.com/paper/2501.07278/) (2025)
- [BLADE: Benchmarking Language Model Agents for Data-Driven Science](https://mlsanity.com/paper/2408.09667/) (2024)
- [From AI for Science to Agentic Science: A Survey on Autonomous Scientific Discovery](https://mlsanity.com/paper/2508.14111/) (2025)
- [InternAgent: When Agent Becomes the Scientist -- Building Closed-Loop System from Hypothesis to Verification](https://mlsanity.com/paper/2505.16938/) (2025)
- [CASCADE: Cumulative Agentic Skill Creation through Autonomous Development and Evolution](https://mlsanity.com/paper/2512.23880/) (2025)
- [MLRC-Bench: Can Language Agents Solve Machine Learning Research Challenges?](https://mlsanity.com/paper/2504.09702/) (2025)
- [MAS-ZERO: Designing Multi-Agent Systems with Zero Supervision](https://mlsanity.com/paper/2505.14996/) (2025)
- [Emergent Coordination in Multi-Agent Language Models](https://mlsanity.com/paper/2510.05174/) (2025)
- [MetaAgent: Automatically Constructing Multi-Agent Systems Based on Finite State Machines](https://mlsanity.com/paper/2507.22606/) (2025)
- [Synthelite: Chemist-aligned and feasibility-aware synthesis planning with LLMs](https://mlsanity.com/paper/2512.16424/) (2025)
- [Evolving Roles of LLMs in Scientific Innovation: Assistant, Collaborator, Scientist, and Evaluator](https://mlsanity.com/paper/2507.11810/) (2025)
- [Beyond Protein Language Models: An Agentic LLM Framework for Mechanistic Enzyme Design](https://mlsanity.com/paper/2511.19423/) (2025)
- [Self-Programming Artificial Intelligence Using Code-Generating Language Models](https://mlsanity.com/paper/2205.00167/) (2022)

## Built on by (most cited first, 1 of 1)

- [Science Done on a Machine by a Machine: AI Agents in Computational Chemistry](https://mlsanity.com/paper/2608.18508/) (2026)

## Abstract (arXiv)

Current Autonomous Scientific Research (ASR) systems, despite leveraging large language models (LLMs) and agentic architectures, remain constrained by fixed workflows and toolsets that prevent adaptation to evolving tasks and environments. We introduce Mimosa, an evolving multi-agent framework that automatically synthesizes task-specific multi-agent workflows and iteratively refines them through experimental feedback. Mimosa leverages the Model Context Protocol (MCP) for dynamic tool discovery, generates workflow topologies via a meta-orchestrator, executes subtasks through code-generating agents that invoke available tools and scientific software libraries, and scores executions with an LLM-based judge whose feedback drives workflow refinement. On ScienceAgentBench, Mimosa achieves a success rate of 43.1% with DeepSeek-V3.2, surpassing both single-agent baselines and static multi-agent configurations. Our results further reveal that models respond heterogeneously to multi-agent decomposition and iterative learning, indicating that the benefits of workflow evolution depend on the capabilities of the underlying execution model. Beyond these benchmarks, Mimosa modular architecture and tool-agnostic design make it readily extensible, and its fully logged execution traces and archived workflows support auditability by preserving every analytical step for inspection and potential replication. Combined with domain-expert guidance, the framework has the potential to automate a broad range of computationally accessible scientific tasks across disciplines. Released as a fully open-source platform, Mimosa aims to provide an open foundation for community-driven ASR.