# DF-ACBlurGAN: Structure-Aware Conditional Generation of Internally Repeated Patterns for Biomaterial Microtopography Design

arXiv: https://arxiv.org/abs/2603.28776 · HTML: https://mlsanity.com/paper/2603.28776/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 9 of its 20 references that are in the map.
- First posted on arXiv 4 Feb 2026.

## Builds on (most cited first, 9 of 9)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [A Style-Based Generator Architecture for Generative Adversarial Networks](https://mlsanity.com/paper/1812.04948/) (2018)
- [Large Scale GAN Training for High Fidelity Natural Image Synthesis](https://mlsanity.com/paper/1809.11096/) (2018)
- [Improved Training of Wasserstein GANs](https://mlsanity.com/paper/1704.00028/) (2017)
- [Watch your Up-Convolution: CNN Based Generative Deep Neural Networks are Failing to Reproduce Spectral Distributions](https://mlsanity.com/paper/2003.01826/) (2020)
- [GAN-based Synthetic Medical Image Augmentation for increased CNN Performance in Liver Lesion Classification](https://mlsanity.com/paper/1803.01229/) (2018)
- [Fourier Spectrum Discrepancies in Deep Network Generated Images](https://mlsanity.com/paper/1911.06465/) (2019)
- [TopologyGAN: Topology Optimization Using Generative Adversarial Networks Based on Physical Fields Over the Initial Domain](https://mlsanity.com/paper/2003.04685/) (2020)

## Abstract (arXiv)

Learning to generate images with internally repeated and periodic structures poses a fundamental challenge for machine learning and computer vision models, which are typically optimised for local texture statistics and semantic realism rather than global structural consistency. This limitation is particularly pronounced in applications requiring strict control over repetition scale, spacing, and boundary coherence, such as microtopographical biomaterial surfaces. In this work, biomaterial design serves as a use case to study conditional generation of repeated patterns under weak supervision and class imbalance. We propose DF-ACBlurGAN, a structure-aware conditional generative adversarial network that explicitly reasons about long-range repetition during training. The approach integrates frequency-domain repetition scale estimation, scale-adaptive Gaussian blurring, and unit-cell reconstruction to balance sharp local features with stable global periodicity. Conditioning on experimentally derived biological response labels, the model synthesises designs aligned with target functional outcomes. Evaluation across multiple biomaterial datasets demonstrates improved repetition consistency and controllable structural variation compared to conventional generative approaches.